4oot

From Proteopedia

(Difference between revisions)

Revision as of 22:03, 5 August 2016

X-ray structure of the protein-gold adduct formed upon reaction of Aubipic with hen egg white lysozyme

Structural highlights

4oot is a 1 chain structure. Full crystallographic information is available from OCA. For a guided tour on the structure components use FirstGlance.
Ligands:	, ,
Related:	4ooo
Activity:	Lysozyme, with EC number 3.2.1.17
Resources:	FirstGlance, OCA, PDBe, RCSB, PDBsum, ProSAT

Function

[LYSC_CHICK] Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents. Has bacteriolytic activity against M.luteus.^[1]

Publication Abstract from PubMed

The structure of the adduct formed in the reaction between Aubipy(c), a cytotoxic organogold(III) compound, and the model protein hen egg white lysozyme (HEWL) has been solved by X-ray crystallography. It emerges that Aubipy(c), after interaction with HEWL, undergoes reduction of the gold(III) center followed by detaching of the cyclometalated ligand; the resulting naked gold(I) ion is found bound to the protein at Gln121. A direct comparison between the present structure and those previously solved for the lysozyme adducts with other gold(III) compounds demonstrates that coordinated ligands play a key role in the protein-metallodrug recognition process. Structural data support the view that gold(III)-based antitumor prodrugs are activated through metal reduction.

Protein Recognition of Gold-Based Drugs: 3D Structure of the Complex Formed When Lysozyme Reacts with Aubipy(c.).,Messori L, Cinellu MA, Merlino A ACS Med Chem Lett. 2014 Jul 31;5(10):1110-3. doi: 10.1021/ml500231b. eCollection , 2014 Oct 9. PMID:25313321^[2]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.

References

↑ Maehashi K, Matano M, Irisawa T, Uchino M, Kashiwagi Y, Watanabe T. Molecular characterization of goose- and chicken-type lysozymes in emu (Dromaius novaehollandiae): evidence for extremely low lysozyme levels in emu egg white. Gene. 2012 Jan 15;492(1):244-9. doi: 10.1016/j.gene.2011.10.021. Epub 2011 Oct, 25. PMID:22044478 doi:10.1016/j.gene.2011.10.021
↑ Messori L, Cinellu MA, Merlino A. Protein Recognition of Gold-Based Drugs: 3D Structure of the Complex Formed When Lysozyme Reacts with Aubipy(c.). ACS Med Chem Lett. 2014 Jul 31;5(10):1110-3. doi: 10.1021/ml500231b. eCollection , 2014 Oct 9. PMID:25313321 doi:http://dx.doi.org/10.1021/ml500231b

1 Structural highlights
2 Function
3 Publication Abstract from PubMed
4 References

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/4oot"

Categories: Lysozyme | Merlino, A | Hydrolase

@@ Line 1: / Line 1: @@
 ==X-ray structure of the protein-gold adduct formed upon reaction of Aubipic with hen egg white lysozyme==
 <StructureSection load='4oot' size='340' side='right' caption='[[4oot]], [[Resolution|resolution]] 1.80&Aring;' scene=''>
@@ Line 6: / Line 7: @@
 <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4ooo|4ooo]]</td></tr>
 <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Lysozyme Lysozyme], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.2.1.17 3.2.1.17] </span></td></tr>
-<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oot OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4oot RCSB], [http://www.ebi.ac.uk/pdbsum/4oot PDBsum]</span></td></tr>
+<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4oot FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4oot OCA], [http://pdbe.org/4oot PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4oot RCSB], [http://www.ebi.ac.uk/pdbsum/4oot PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4oot ProSAT]</span></td></tr>
 </table>
 == Function ==
@@ Line 18: / Line 19: @@
 From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
 </div>
+<div class="pdbe-citations 4oot" style="background-color:#fffaf0;"></div>
 == References ==
 <references/>

4oot

From Proteopedia

Revision as of 22:03, 5 August 2016

X-ray structure of the protein-gold adduct formed upon reaction of Aubipic with hen egg white lysozyme

Structural highlights

Function

Publication Abstract from PubMed

References

Contents

Proteopedia Page Contributors and Editors (what is this?)

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