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3lcu

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==Crystal Structure of Antibiotic related Methyltransferase==
==Crystal Structure of Antibiotic related Methyltransferase==
<StructureSection load='3lcu' size='340' side='right' caption='[[3lcu]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='3lcu' size='340' side='right' caption='[[3lcu]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
== Structural highlights ==
== Structural highlights ==
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<table><tr><td colspan='2'>[[3lcu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Micromonospora_zionensis Micromonospora zionensis]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LCU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LCU FirstGlance]. <br>
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<table><tr><td colspan='2'>[[3lcu]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/"micromonospora_zionensis"_marquez_et_al. "micromonospora zionensis" marquez et al.]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3LCU OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3LCU FirstGlance]. <br>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=SAH:S-ADENOSYL-L-HOMOCYSTEINE'>SAH</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3lcv|3lcv]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3lcv|3lcv]]</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lcu OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3lcu RCSB], [http://www.ebi.ac.uk/pdbsum/3lcu PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3lcu FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3lcu OCA], [http://pdbe.org/3lcu PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3lcu RCSB], [http://www.ebi.ac.uk/pdbsum/3lcu PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3lcu ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q7M0R2_9ACTO Q7M0R2_9ACTO]] Specifically methylates the N(7) position of guanine 1405 in 16S rRNA. Confers resistance to various aminoglycosides, including gentamicin, kanamycin and sisomicin.<ref>PMID:1447159</ref> <ref>PMID:19589804</ref>
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[[http://www.uniprot.org/uniprot/SGM_MICZI SGM_MICZI]] Specifically methylates the N(7) position of guanine 1405 in 16S rRNA. Confers resistance to various aminoglycosides, including gentamicin, kanamycin and sisomicin.<ref>PMID:1447159</ref> <ref>PMID:19589804</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3lcu ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3lcu" style="background-color:#fffaf0;"></div>
== References ==
== References ==
<references/>
<references/>
__TOC__
__TOC__
</StructureSection>
</StructureSection>
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[[Category: Micromonospora zionensis]]
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[[Category: Micromonospora zionensis marquez et al]]
[[Category: Husain, N]]
[[Category: Husain, N]]
[[Category: Sivaraman, J]]
[[Category: Sivaraman, J]]

Revision as of 22:04, 5 August 2016

Crystal Structure of Antibiotic related Methyltransferase

3lcu, resolution 2.10Å

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