1n3n
From Proteopedia
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|PDB= 1n3n |SIZE=350|CAPTION= <scene name='initialview01'>1n3n</scene>, resolution 3.0Å | |PDB= 1n3n |SIZE=350|CAPTION= <scene name='initialview01'>1n3n</scene>, resolution 3.0Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=SO4:SULFATE ION'>SO4</scene> | + | |LIGAND= <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n3n FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n3n OCA], [http://www.ebi.ac.uk/pdbsum/1n3n PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1n3n RCSB]</span> | ||
}} | }} | ||
| Line 28: | Line 31: | ||
[[Category: Pluckthun, A.]] | [[Category: Pluckthun, A.]] | ||
[[Category: Tissot, A C.]] | [[Category: Tissot, A C.]] | ||
| - | [[Category: SO4]] | ||
[[Category: immunoglobulin fold]] | [[Category: immunoglobulin fold]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:24:54 2008'' |
Revision as of 19:24, 30 March 2008
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| , resolution 3.0Å | |||||||
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| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Crystal structure of a mycobacterial hsp60 epitope with the murine class I MHC molecule H-2Db
Overview
The decameric peptide SALQNAASIA from the Mycobacterium bovis heat shock protein (hsp) 60 is recognized by the murine T-cell receptor UZ-3-4 in complex with the murine class I major histocompatibility complex molecule H-2D(b). This T-cell receptor cross-reacts with the H-2D(b)-bound non-homologous decameric peptide KDIGNIISDA from the murine hsp60, but does not recognize the nonameric mycobacterial peptide SALQNAASI. Cross-recognition of the KDIGNIISDA/H-2D(b) complex induces autoimmune pathology in immunodeficient mice. We solved the X-ray crystal structure of the SALQNAASIA/H-2D(b) complex at 3.0 A resolution, and we modelled the KDIGNIISDA and SALQNAASI peptides in the H-2D(b) binding site. The structural analysis of the H-2D(b)-bound hsp60 epitopes offers insight into T-cell receptor cross-reactivity.
About this Structure
1N3N is a Protein complex structure of sequences from Mus musculus. Full crystallographic information is available from OCA.
Reference
Structural analysis of mycobacterial and murine hsp60 epitopes in complex with the class I MHC molecule H-2Db., Ciatto C, Capitani G, Tissot AC, Pecorari F, Pluckthun A, Grutter MG, FEBS Lett. 2003 May 22;543(1-3):11-5. PMID:12753896
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