4gm9

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==Crystal structure of human WD repeat domain 5 with compound MM-401==
==Crystal structure of human WD repeat domain 5 with compound MM-401==
<StructureSection load='4gm9' size='340' side='right' caption='[[4gm9]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
<StructureSection load='4gm9' size='340' side='right' caption='[[4gm9]], [[Resolution|resolution]] 2.10&Aring;' scene=''>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gm3|4gm3]], [[4gm8|4gm8]], [[4gmb|4gmb]]</td></tr>
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gm3|4gm3]], [[4gm8|4gm8]], [[4gmb|4gmb]]</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">WDR5, BIG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">WDR5, BIG3 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gm9 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4gm9 RCSB], [http://www.ebi.ac.uk/pdbsum/4gm9 PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4gm9 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4gm9 OCA], [http://pdbe.org/4gm9 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4gm9 RCSB], [http://www.ebi.ac.uk/pdbsum/4gm9 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4gm9 ProSAT]</span></td></tr>
</table>
</table>
== Function ==
== Function ==
[[http://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
[[http://www.uniprot.org/uniprot/WDR5_HUMAN WDR5_HUMAN]] Contributes to histone modification. May position the N-terminus of histone H3 for efficient trimethylation at 'Lys-4'. As part of the MLL1/MLL complex it is involved in methylation and dimethylation at 'Lys-4' of histone H3. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation. As part of the NSL complex it may be involved in acetylation of nucleosomal histone H4 on several lysine residues. May regulate osteoblasts differentiation.<ref>PMID:19556245</ref> <ref>PMID:19103755</ref> <ref>PMID:20018852</ref> <ref>PMID:16600877</ref> <ref>PMID:16829960</ref>
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==See Also==
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*[[WD-repeat protein 5|WD-repeat protein 5]]
== References ==
== References ==
<references/>
<references/>

Revision as of 22:12, 5 August 2016

Crystal structure of human WD repeat domain 5 with compound MM-401

4gm9, resolution 2.10Å

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