This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


Retinoid X receptor

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
- 
<StructureSection load='1fby' size='350' side='right' caption='Structure of human retinoid X receptor α ligand-binding domain complex with 9-cis retinoic acid (PDB entry [[1fby]])' scene=''>
<StructureSection load='1fby' size='350' side='right' caption='Structure of human retinoid X receptor α ligand-binding domain complex with 9-cis retinoic acid (PDB entry [[1fby]])' scene=''>
== Function ==
== Function ==
Line 9: Line 8:
== Relevance ==
== Relevance ==
-
*RXRγ is involved in working memory and despair behavior<ref>PMID:21334601</ref>. RXR pathway is a positive regulator of myelin debris clearance and has a role in age-related decline in remyelination<ref>PMID:26463675</ref>. <br />
+
RXRγ is involved in working memory and despair behavior<ref>PMID:21334601</ref>. RXR pathway is a positive regulator of myelin debris clearance and has a role in age-related decline in remyelination<ref>PMID:26463675</ref>. <br />
== Structural highlights ==
== Structural highlights ==
-
9-''cis'' retinoid acid binds to RXRα LBD in a hydrophobic pocket. The ligand-binding residues are conserved in the 3 types of RXR
+
9-''cis'' retinoid acid binds to RXRα LBD in a hydrophobic pocket. The ligand-binding residues are conserved in the 3 classes of RXR
<ref>PMID:10835357</ref>.
<ref>PMID:10835357</ref>.
</StructureSection>
</StructureSection>

Revision as of 08:26, 8 August 2016

Structure of human retinoid X receptor α ligand-binding domain complex with 9-cis retinoic acid (PDB entry 1fby)

Drag the structure with the mouse to rotate

3D structures of retinoid X receptor

Updated on 08-August-2016

References

  1. ↑ Dawson MI, Xia Z. The retinoid X receptors and their ligands. Biochim Biophys Acta. 2012 Jan;1821(1):21-56. doi: 10.1016/j.bbalip.2011.09.014. , Epub 2011 Oct 1. PMID:22020178 doi:http://dx.doi.org/10.1016/j.bbalip.2011.09.014
  2. ↑ Wu Y, Zhang X, Bardag-Gorce F, Robel RC, Aguilo J, Chen L, Zeng Y, Hwang K, French SW, Lu SC, Wan YJ. Retinoid X receptor alpha regulates glutathione homeostasis and xenobiotic detoxification processes in mouse liver. Mol Pharmacol. 2004 Mar;65(3):550-7. PMID:14978233 doi:http://dx.doi.org/10.1124/mol.65.3.550
  3. ↑ Wietrzych-Schindler M, Szyszka-Niagolov M, Ohta K, Endo Y, Perez E, de Lera AR, Chambon P, Krezel W. Retinoid x receptor gamma is implicated in docosahexaenoic acid modulation of despair behaviors and working memory in mice. Biol Psychiatry. 2011 Apr 15;69(8):788-94. doi: 10.1016/j.biopsych.2010.12.017., Epub 2011 Feb 21. PMID:21334601 doi:http://dx.doi.org/10.1016/j.biopsych.2010.12.017
  4. ↑ Natrajan MS, de la Fuente AG, Crawford AH, Linehan E, Nunez V, Johnson KR, Wu T, Fitzgerald DC, Ricote M, Bielekova B, Franklin RJ. Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination. Brain. 2015 Dec;138(Pt 12):3581-97. doi: 10.1093/brain/awv289. Epub 2015 Oct 12. PMID:26463675 doi:http://dx.doi.org/10.1093/brain/awv289
  5. ↑ Egea PF, Mitschler A, Rochel N, Ruff M, Chambon P, Moras D. Crystal structure of the human RXRalpha ligand-binding domain bound to its natural ligand: 9-cis retinoic acid. EMBO J. 2000 Jun 1;19(11):2592-601. PMID:10835357 doi:10.1093/emboj/19.11.2592

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Retinoid_X_receptor"
Personal tools