Retinol-binding protein

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{{STRUCTURE_2rct| PDB=2rct | SIZE=400| SCENE= |right|CAPTION=Human cellular retinol-binding protein II complex with retinol, sulfate and tartarate, [[2rct]] }}
{{STRUCTURE_2rct| PDB=2rct | SIZE=400| SCENE= |right|CAPTION=Human cellular retinol-binding protein II complex with retinol, sulfate and tartarate, [[2rct]] }}
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== Function ==
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'''Retinol-binding protein''' (RBP) are carrier proteins which bind retinol (vitamin A alcohol). Human RBP4 is the carrier of retinol in the blood. It delivers retinol from the liver to the peripheral tissues. RBP also functions in regulation, metabolism and activities of retinoids. Retinol is being protected from oxidation and becomes soluble when bound to RBP. RBP is classified according to its site of activity. '''Plasma RBP''' (PRBP) carries retinol in blood<ref>PMID:6994566</ref> while '''cellular RBP''' (CRBP) carries retinol in the cell<ref>PMID:2825608</ref>.
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== Relevance ==
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RBP is used to assess vitamin A deficiency as it binds 1:1 to retinol.
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'''Retinol-binding protein''' (RBP) are carrier proteins which bind retinol (vitamin A alcohol). Human RBP4 is the carrier of retinol in the blood. It delivers retinol from the liver to the peripheral tissues. RBP also functions in regulation, metabolism and activities of retinoids. Retinol is being protected from oxidation and becomes soluble when bound to RBP. RBP is used to assess vitamin A deficiency as it binds 1:1 to retinol. RBP is classified according to its site of activity. Plasma RBP (PRBP) carries retinol in blood while cellular RBP (CRBP) carries retinol in the cell.
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==3D structures of retinol-binding protein==
==3D structures of retinol-binding protein==
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**[[1crb]], [[1opb]] - rRBP + retinol<br />
**[[1crb]], [[1opb]] - rRBP + retinol<br />
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:05, 8 August 2016

Template:STRUCTURE 2rct

Contents

Function

Retinol-binding protein (RBP) are carrier proteins which bind retinol (vitamin A alcohol). Human RBP4 is the carrier of retinol in the blood. It delivers retinol from the liver to the peripheral tissues. RBP also functions in regulation, metabolism and activities of retinoids. Retinol is being protected from oxidation and becomes soluble when bound to RBP. RBP is classified according to its site of activity. Plasma RBP (PRBP) carries retinol in blood[1] while cellular RBP (CRBP) carries retinol in the cell[2].

Relevance

RBP is used to assess vitamin A deficiency as it binds 1:1 to retinol.

3D structures of retinol-binding protein

Updated on 08-August-2016

References

  1. ↑ Goodman DS. Plasma retinol-binding protein. Ann N Y Acad Sci. 1980;348:378-90. PMID:6994566
  2. ↑ Ong DE. Cellular retinoid-binding proteins. Arch Dermatol. 1987 Dec;123(12):1693-1695a. PMID:2825608

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

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