Rho guanine nucleotide exchange factor

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<StructureSection load='3kz1' size='340' side='right' caption='Human Rho guanine nucleotide exchange factor 11 DH/PH domain (grey and green) complex with transforming protein RhoA (magenta and cyan), GSP and Mg+2 ion (PDB code [[3kz1]])' scene=''>
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<StructureSection load='3kz1' size='340' side='right' caption='Human Rho guanine nucleotide exchange factor 11 DH/PH domain (grey) complex with transforming protein RhoA (cyan), GSP (stick model) and Mg+2 ion (green) (PDB code [[3kz1]])' scene=''>
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'''Rho guanine nucleotide exchange factor''' (Rho) stimulate the exchange of the inactive GDP-bound GTPase to its active GTP-bound form. Binding of Rho to GDP-GTPase catalyzes the dissociation of GDP from the protein. Rho domains include the catalytic DH/PH (Dbl Homology/Pleckstrin Homology) domain; the CH (Calponin Homology) domain is believed to be involved in calcium regulation; the SH3 domain interacts with proline-rich sequences.
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== Function ==
== Function ==
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'''Rho guanine nucleotide exchange factor''' (GEF) stimulate the exchange of the inactive GDP-bound GTPase to its active GTP-bound form. Binding of GEF to GDP-GTPase catalyzes the dissociation of GDP from the protein<ref>PMID:23303910</ref>. GEF domains include the catalytic DH/PH (Dbl Homology/Pleckstrin Homology) domain; the CH (Calponin Homology) domain is believed to be involved in calcium regulation; the SH3 domain interacts with proline-rich sequences.
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*'''Rho guanine nucleotide exchange factor 1''' binds to G proteins and stimulate Rho-dependent signals.<br />
== Disease ==
== Disease ==
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*Rho guanine nucleotide exchange factor 1 (P115-RhoGEF)
*Rho guanine nucleotide exchange factor 1 (P115-RhoGEF)
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**[[1iap]] – hRho N terminal - human<br />
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**[[1iap]] – hGEF N terminal - human<br />
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**[[3odo]], [[3odw]], [[3odx]] – hRho DH/PH domain <br />
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**[[3odo]], [[3odw]], [[3odx]] – hGEF DH/PH domain <br />
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**[[3p6a]] – hRho DH/PH domain (mutant)<br />
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**[[3p6a]] – hGEF DH/PH domain (mutant)<br />
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**[[1shz]], [[3ab3]] – hRho N terminal + guanine nucleotide-binding protein<br />
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**[[1shz]], [[3ab3]] – hGEF N terminal + guanine nucleotide-binding protein<br />
*Rho guanine nucleotide exchange factor 4 (Asef)
*Rho guanine nucleotide exchange factor 4 (Asef)
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**[[2dx1]], [[2pz1]] – hRho <br />
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**[[2dx1]], [[2pz1]] – hGEF <br />
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**[[3nmx]], [[3nmz]] – hRho + APC variant protein<br />
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**[[3nmx]], [[3nmz]] – hGEF + APC variant protein<br />
*Rho guanine nucleotide exchange factor 6
*Rho guanine nucleotide exchange factor 6
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**[[1ujy]] – hRho SH3 domain - NMR<br />
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**[[1ujy]] – hGEF SH3 domain - NMR<br />
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**[[1wyr]] – hRho CH domain - NMR<br />
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**[[1wyr]] – hGEF CH domain - NMR<br />
*Rho guanine nucleotide exchange factor 7 (β-PIX)
*Rho guanine nucleotide exchange factor 7 (β-PIX)
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**[[1by1]] – hRho DH domain - NMR<br />
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**[[1by1]] – hGEF DH domain - NMR<br />
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**[[2l3g]] – hRho CH domain - NMR<br />
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**[[2l3g]] – hGEF CH domain - NMR<br />
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**[[2esw]] – Rho SH3 domain – mouse<br />
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**[[2esw]] – GEF SH3 domain – mouse<br />
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**[[2g6f]] – rRho SH3 domain – rat<br />
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**[[2g6f]] – rGEF SH3 domain – rat<br />
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**[[2w6b]] – rRho coiled-coil domain <br />
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**[[2w6b]] – rGEF coiled-coil domain <br />
*Rho guanine nucleotide exchange factor 7 complex with peptide
*Rho guanine nucleotide exchange factor 7 complex with peptide
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**[[2ak5]] – hRho SH3 domain + CBL-b peptide <br />
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**[[2ak5]] – hGEF SH3 domain + CBL-b peptide <br />
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**[[2df6]] – hRho SH3 domain + PAK-1 peptide <br />
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**[[2df6]] – hGEF SH3 domain + PAK-1 peptide <br />
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**[[1zsg]] – hRho residues 179-243 + PAK-1 peptide – NMR<br />
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**[[1zsg]] – hGEF residues 179-243 + PAK-1 peptide – NMR<br />
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**[[2p4r]] – rRho SH3 domain + E3 ubiquitin protein ligase peptide <br />
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**[[2p4r]] – rGEF SH3 domain + E3 ubiquitin protein ligase peptide <br />
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**[[3l4f]] – rRho coiled-coil domain + SHANK1 PDZ domain <br />
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**[[3l4f]] – rGEF coiled-coil domain + SHANK1 PDZ domain <br />
*Rho guanine nucleotide exchange factor 8 (PRONE8)
*Rho guanine nucleotide exchange factor 8 (PRONE8)
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**[[2ntx]] – AtRho PRONE domain – ''Arabidopasis thaliana''<br />
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**[[2ntx]] – AtGEF PRONE domain – ''Arabidopasis thaliana''<br />
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**[[2wbl]] – AtRho PRONE domain + GTPase ROP7 <br />
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**[[2wbl]] – AtGEF PRONE domain + GTPase ROP7 <br />
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**[[2nty]] – AtRho PRONE domain + GTPase ROP4 + GDP <br />
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**[[2nty]] – AtGEF PRONE domain + GTPase ROP4 + GDP <br />
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**[[3eo2]] – hRho residues 161-373 <br />
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**[[3eo2]] – hGEF residues 161-373 <br />
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**[[4xh9]] – hRho DH/PH domain + transforming protein RhoA <br />
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**[[4xh9]] – hGEF DH/PH domain + transforming protein RhoA <br />
*Rho guanine nucleotide exchange factor 9 (collybistin)
*Rho guanine nucleotide exchange factor 9 (collybistin)
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**[[2ysq]] – hRho SH3 domain - NMR<br />
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**[[2ysq]] – hGEF SH3 domain - NMR<br />
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**[[4mt6]], [[4mt7]] – rRho (mutant)<br />
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**[[4mt6]], [[4mt7]] – rGEF (mutant)<br />
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**[[2dfk]] – rRho + CDC42 <br />
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**[[2dfk]] – rGEF + CDC42 <br />
*Rho guanine nucleotide exchange factor 11
*Rho guanine nucleotide exchange factor 11
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**[[2dls]] – hRho PDZ domain - NMR<br />
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**[[2dls]] – hGEF PDZ domain - NMR<br />
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**[[3kz1]], [[3t06]] – hRho DH/PH domain + transforming protein RhoA <br />
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**[[3kz1]], [[3t06]] – hGEF DH/PH domain + transforming protein RhoA <br />
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**[[1xcg]] – hRho DH/PH domain + transforming protein RhoA - NMR<br />
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**[[1xcg]] – hGEF DH/PH domain + transforming protein RhoA - NMR<br />
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**[[3cx6]] – rRho RGS domain + guanine nucleotide-binding protein <br />
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**[[3cx6]] – rGEF RGS domain + guanine nucleotide-binding protein <br />
*Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF)
*Rho guanine nucleotide exchange factor 12 (Leukemia-associated RhoGEF)
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**[[1txd]] – hRho DH/PH domain <br />
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**[[1txd]] – hGEF DH/PH domain <br />
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**[[2omj]] – hRho PDZ domain <br />
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**[[2omj]] – hGEF PDZ domain <br />
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**[[1x86]] – hRho DH/PH domain (mutant) + transforming protein RhoA <br />
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**[[1x86]] – hGEF DH/PH domain (mutant) + transforming protein RhoA <br />
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**[[2os6]] – hRho PDZ domain + plexin peptide – NMR<br />
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**[[2os6]] – hGEF PDZ domain + plexin peptide – NMR<br />
*Rho guanine nucleotide exchange factor 16
*Rho guanine nucleotide exchange factor 16
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**[[1x6b]] – hRho SH3 domain - NMR<br />
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**[[1x6b]] – hGEF SH3 domain - NMR<br />
}}
}}
== References ==
== References ==
<references/>
<references/>

Revision as of 06:48, 9 August 2016

Human Rho guanine nucleotide exchange factor 11 DH/PH domain (grey) complex with transforming protein RhoA (cyan), GSP (stick model) and Mg+2 ion (green) (PDB code 3kz1)

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3D Structures of Rho guanine nucleotide exchange factor

Updated on 09-August-2016

References

  1. ↑ Cherfils J, Zeghouf M. Regulation of small GTPases by GEFs, GAPs, and GDIs. Physiol Rev. 2013 Jan;93(1):269-309. doi: 10.1152/physrev.00003.2012. PMID:23303910 doi:http://dx.doi.org/10.1152/physrev.00003.2012

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Michal Harel, Joel L. Sussman

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