1n7u
From Proteopedia
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|PDB= 1n7u |SIZE=350|CAPTION= <scene name='initialview01'>1n7u</scene>, resolution 2.40Å | |PDB= 1n7u |SIZE=350|CAPTION= <scene name='initialview01'>1n7u</scene>, resolution 2.40Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene> | + | |LIGAND= <scene name='pdbligand=ACT:ACETATE+ION'>ACT</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= II ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10658 Enterobacteria phage PRD1]) | |GENE= II ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=10658 Enterobacteria phage PRD1]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1n7v|1N7V]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1n7u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1n7u OCA], [http://www.ebi.ac.uk/pdbsum/1n7u PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1n7u RCSB]</span> | ||
}} | }} | ||
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[[Category: Butcher, S J.]] | [[Category: Butcher, S J.]] | ||
[[Category: Xu, L.]] | [[Category: Xu, L.]] | ||
| - | [[Category: ACT]] | ||
| - | [[Category: CA]] | ||
[[Category: antibiotic-resistance]] | [[Category: antibiotic-resistance]] | ||
[[Category: bacteriophage prd1]] | [[Category: bacteriophage prd1]] | ||
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[[Category: viral receptor-binding]] | [[Category: viral receptor-binding]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:26:36 2008'' |
Revision as of 19:26, 30 March 2008
| |||||||
| , resolution 2.40Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , | ||||||
| Gene: | II (Enterobacteria phage PRD1) | ||||||
| Related: | 1N7V
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
THE RECEPTOR-BINDING PROTEIN P2 OF BACTERIOPHAGE PRD1: CRYSTAL FORM I
Overview
Bacteriophage PRD1 is unusual, with an internal lipid membrane, but has striking resemblances to adenovirus that include receptor binding spikes. The PRD1 vertex complex contains P2, a 590 residue monomer that binds to receptors on antibiotic-resistant strains of E. coli and so is the functional counterpart to adenovirus fiber. P2 structures from two crystal forms, at 2.2 and 2.4 A resolution, reveal an elongated club-shaped molecule with a novel beta propeller "head" showing pseudo-6-fold symmetry. An extended loop with another novel fold forms a long "tail" containing a protruding proline-rich "fin." The head and fin structures are well suited to recognition and attachment, and the tail is likely to trigger the processes of vertex disassembly, membrane tube formation, and subsequent DNA injection.
About this Structure
1N7U is a Single protein structure of sequence from Enterobacteria phage prd1. Full crystallographic information is available from OCA.
Reference
The receptor binding protein P2 of PRD1, a virus targeting antibiotic-resistant bacteria, has a novel fold suggesting multiple functions., Xu L, Benson SD, Butcher SJ, Bamford DH, Burnett RM, Structure. 2003 Mar;11(3):309-22. PMID:12623018
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