1na1
From Proteopedia
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|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1na1 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1na1 OCA], [http://www.ebi.ac.uk/pdbsum/1na1 PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1na1 RCSB]</span> | ||
}} | }} | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1NA1 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/ | + | 1NA1 is a [[Protein complex]] structure of sequences from [http://en.wikipedia.org/wiki/Human_rhinovirus_14 Human rhinovirus 14]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1NA1 OCA]. |
==Reference== | ==Reference== | ||
Structural and virological studies of the stages of virus replication that are affected by antirhinovirus compounds., Zhang Y, Simpson AA, Ledford RM, Bator CM, Chakravarty S, Skochko GA, Demenczuk TM, Watanyar A, Pevear DC, Rossmann MG, J Virol. 2004 Oct;78(20):11061-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15452226 15452226] | Structural and virological studies of the stages of virus replication that are affected by antirhinovirus compounds., Zhang Y, Simpson AA, Ledford RM, Bator CM, Chakravarty S, Skochko GA, Demenczuk TM, Watanyar A, Pevear DC, Rossmann MG, J Virol. 2004 Oct;78(20):11061-9. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15452226 15452226] | ||
| - | [[Category: Human rhinovirus | + | [[Category: Human rhinovirus 14]] |
[[Category: Protein complex]] | [[Category: Protein complex]] | ||
[[Category: Bator, C M.]] | [[Category: Bator, C M.]] | ||
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[[Category: Tull, T M.]] | [[Category: Tull, T M.]] | ||
[[Category: Zhang, Y.]] | [[Category: Zhang, Y.]] | ||
| - | [[Category: W11]] | ||
[[Category: hrv14]] | [[Category: hrv14]] | ||
[[Category: human rhinovirus 14]] | [[Category: human rhinovirus 14]] | ||
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[[Category: pleconaril]] | [[Category: pleconaril]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:27:28 2008'' |
Revision as of 19:27, 30 March 2008
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| , resolution 3.3Å | |||||||
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| Ligands: | |||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
The structure of HRV14 when complexed with Pleconaril
Overview
Pleconaril is a broad-spectrum antirhinovirus and antienterovirus compound that binds into a hydrophobic pocket within viral protein 1, stabilizing the capsid and resulting in the inhibition of cell attachment and RNA uncoating. When crystals of human rhinovirus 16 (HRV16) and HRV14 are incubated with pleconaril, drug occupancy in the binding pocket is lower than when pleconaril is introduced during assembly prior to crystallization. This effect is far more marked in HRV16 than in HRV14 and is more marked with pleconaril than with other compounds. These observations are consistent with virus yield inhibition studies and radiolabeled drug binding studies showing that the antiviral effect of pleconaril against HRV16 is greater on the infectivity of progeny virions than the parent input viruses. These data suggest that drug integration into the binding pocket during assembly, or at some other late stage in virus replication, may contribute to the antiviral activity of capsid binding compounds.
About this Structure
1NA1 is a Protein complex structure of sequences from Human rhinovirus 14. Full crystallographic information is available from OCA.
Reference
Structural and virological studies of the stages of virus replication that are affected by antirhinovirus compounds., Zhang Y, Simpson AA, Ledford RM, Bator CM, Chakravarty S, Skochko GA, Demenczuk TM, Watanyar A, Pevear DC, Rossmann MG, J Virol. 2004 Oct;78(20):11061-9. PMID:15452226
Page seeded by OCA on Sun Mar 30 22:27:28 2008
