5d55

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'''Unreleased structure'''
 
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The entry 5d55 is ON HOLD until Paper Publication
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==Crystal structure of the E. coli Hda pilus minor tip subunit, HdaB==
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<StructureSection load='5d55' size='340' side='right' caption='[[5d55]], [[Resolution|resolution]] 2.00&Aring;' scene=''>
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5d55]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D55 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D55 FirstGlance]. <br>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=FLC:CITRATE+ANION'>FLC</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d55 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d55 OCA], [http://pdbe.org/5d55 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d55 RCSB], [http://www.ebi.ac.uk/pdbsum/5d55 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5d55 ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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Enteroaggregative Escherichia coli is the primary cause of pediatric diarrhea in developing countries. They utilize aggregative adherence fimbriae (AAFs) to promote initial adherence to the host intestinal mucosa, promote the formation of biofilms, and mediate host invasion. Five AAFs have been identified to date and AAF/IV is amongst the most prevalent found in clinical isolates. Here we present the X-ray crystal structure of the AAF/IV tip protein HdaB at 2.0 A resolution. It shares high structural homology with members of the Afa/Dr superfamily of fimbriae, which are involved in host invasion. We highlight surface exposed residues that share sequence homology and propose that these may function in invasion and also non-conserved regions that could mediate HdaB specific adhesive functions.
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Authors:
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Crystal structure and analysis of HdaB: The enteroaggregative Escherichia coli AAF/IV pilus tip protein.,Lee WC, Matthews S, Garnett JA Protein Sci. 2016 Jul 12. doi: 10.1002/pro.2982. PMID:27400770<ref>PMID:27400770</ref>
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Description:
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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[[Category: Unreleased Structures]]
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</div>
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<div class="pdbe-citations 5d55" style="background-color:#fffaf0;"></div>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Garnett, J A]]
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[[Category: Lee, W C]]
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[[Category: Matthews, S J]]
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[[Category: Biofilm]]
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[[Category: Cell adhesion]]
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[[Category: Chaperone-usher]]
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[[Category: Hda]]
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[[Category: Pilus]]

Revision as of 15:52, 10 August 2016

Crystal structure of the E. coli Hda pilus minor tip subunit, HdaB

5d55, resolution 2.00Å

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