5lh8
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==Trypsin inhibitors for the treatment of pancreatitis - cpd 8== | |
| + | <StructureSection load='5lh8' size='340' side='right' caption='[[5lh8]], [[Resolution|resolution]] 1.54Å' scene=''> | ||
| + | == Structural highlights == | ||
| + | <table><tr><td colspan='2'>[[5lh8]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Bos_taurus Bos taurus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5LH8 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5LH8 FirstGlance]. <br> | ||
| + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=6WH:(2~{S},4~{S})-1-[4-(AMINOMETHYL)-3-METHOXY-PHENYL]CARBONYL-4-(4-CYCLOPROPYL-1,2,3-TRIAZOL-1-YL)-~{N}-[(1~{S},2~{R})-2-PHENYLCYCLOHEXYL]PYRROLIDINE-2-CARBOXAMIDE'>6WH</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=DMS:DIMETHYL+SULFOXIDE'>DMS</scene></td></tr> | ||
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Trypsin Trypsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.21.4 3.4.21.4] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5lh8 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5lh8 OCA], [http://pdbe.org/5lh8 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5lh8 RCSB], [http://www.ebi.ac.uk/pdbsum/5lh8 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5lh8 ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | <div style="background-color:#fffaf0;"> | ||
| + | == Publication Abstract from PubMed == | ||
| + | Proline-based trypsin inhibitors occupying the S1-S2-S1' region were identified by an HTS screening campaign. It was discovered that truncation of the P1' moiety and appropriate extension into the S4 region led to highly potent trypsin inhibitors with excellent selectivity against related serine proteases and a favorable hERG profile. | ||
| - | + | Trypsin inhibitors for the treatment of pancreatitis.,Brandl T, Simic O, Skaanderup PR, Namoto K, Berst F, Ehrhardt C, Schiering N, Mueller I, Woelcke J Bioorg Med Chem Lett. 2016 Jul 17. pii: S0960-894X(16)30742-9. doi:, 10.1016/j.bmcl.2016.07.029. PMID:27476144<ref>PMID:27476144</ref> | |
| - | + | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | |
| - | [[Category: | + | </div> |
| + | <div class="pdbe-citations 5lh8" style="background-color:#fffaf0;"></div> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Bos taurus]] | ||
| + | [[Category: Trypsin]] | ||
| + | [[Category: Arcy, A D]] | ||
[[Category: Brandl, T]] | [[Category: Brandl, T]] | ||
| - | [[Category: Woelcke, J]] | ||
| - | [[Category: Skaanderup, P]] | ||
| - | [[Category: D'Arcy, A]] | ||
[[Category: Schiering, N]] | [[Category: Schiering, N]] | ||
[[Category: Simic, O]] | [[Category: Simic, O]] | ||
| + | [[Category: Skaanderup, P]] | ||
| + | [[Category: Woelcke, J]] | ||
| + | [[Category: Complex]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Inhibitor]] | ||
| + | [[Category: Pancreatitis]] | ||
| + | [[Category: S1 protease]] | ||
Revision as of 16:06, 10 August 2016
Trypsin inhibitors for the treatment of pancreatitis - cpd 8
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Categories: Bos taurus | Trypsin | Arcy, A D | Brandl, T | Schiering, N | Simic, O | Skaanderup, P | Woelcke, J | Complex | Hydrolase | Inhibitor | Pancreatitis | S1 protease
