This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.
Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.
5cxa
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the catalytic domain of Human MMP12 in complex with a carboxylate inhibitor related to RXP470== | |
| - | + | <StructureSection load='5cxa' size='340' side='right' caption='[[5cxa]], [[Resolution|resolution]] 1.30Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5cxa]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5CXA OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5CXA FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=55L:(R)-4-(((S)-1-(((S)-1-AMINO-4-CARBOXY-1-OXOBUTAN-2-YL)AMINO)-4-CARBOXY-1-OXOBUTAN-2-YL)AMINO)-3-((3-(3-CHLORO-[1,1-BIPHENYL]-4-YL)ISOXAZOL-5-YL)METHYL)-4-OXOBUTANOATE'>55L</scene>, <scene name='pdbligand=CA:CALCIUM+ION'>CA</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | |
| - | [[Category: | + | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4gql|4gql]], [[4gr3|4gr3]], [[4gr0|4gr0]], [[4gr8|4gr8]]</td></tr> |
| + | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Macrophage_elastase Macrophage elastase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.24.65 3.4.24.65] </span></td></tr> | ||
| + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5cxa FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5cxa OCA], [http://pdbe.org/5cxa PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5cxa RCSB], [http://www.ebi.ac.uk/pdbsum/5cxa PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5cxa ProSAT]</span></td></tr> | ||
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/MMP12_HUMAN MMP12_HUMAN]] May be involved in tissue injury and remodeling. Has significant elastolytic activity. Can accept large and small amino acids at the P1' site, but has a preference for leucine. Aromatic or hydrophobic residues are preferred at the P1 site, with small hydrophobic residues (preferably alanine) occupying P3. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Macrophage elastase]] | ||
| + | [[Category: Devel, L]] | ||
[[Category: Dive, V]] | [[Category: Dive, V]] | ||
| - | [[Category: Devel, L]] | ||
[[Category: Rouanet-Mehouas, C]] | [[Category: Rouanet-Mehouas, C]] | ||
| - | [[Category: Stura, E | + | [[Category: Stura, E A]] |
| + | [[Category: Carboxylate based inhibitor]] | ||
| + | [[Category: Carboxylate peptidic inhibitor]] | ||
| + | [[Category: Hydrolase]] | ||
| + | [[Category: Metzincin]] | ||
| + | [[Category: Rxp470]] | ||
Revision as of 16:20, 10 August 2016
Crystal structure of the catalytic domain of Human MMP12 in complex with a carboxylate inhibitor related to RXP470
| |||||||||||
