5d9g
From Proteopedia
(Difference between revisions)
| Line 1: | Line 1: | ||
| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of TIPRL, TOR signaling pathway regulator-like, in complex with peptide== | |
| - | + | <StructureSection load='5d9g' size='340' side='right' caption='[[5d9g]], [[Resolution|resolution]] 2.15Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5d9g]] is a 4 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5D9G OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5D9G FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=NI:NICKEL+(II)+ION'>NI</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene></td></tr> | |
| - | [[ | + | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5d9g FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5d9g OCA], [http://pdbe.org/5d9g PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5d9g RCSB], [http://www.ebi.ac.uk/pdbsum/5d9g PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5d9g ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/TIPRL_HUMAN TIPRL_HUMAN]] May be a allosteric regulator of serine/threonine-protein phosphatase 2A (PP2A). Isoform 1 inhibits catalytic activity of the PP2A(D) core complex in vitro. The PP2A(C):TIPRL complex does not show phosphatase activity. May play a role in the regulation of ATM/ATR signaling pathway controlling DNA replication and repair.<ref>PMID:17384681</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Aparicio, R]] | [[Category: Aparicio, R]] | ||
[[Category: Brandao-Neto, J]] | [[Category: Brandao-Neto, J]] | ||
| - | [[Category: Pereira, H | + | [[Category: Pereira, H M]] |
| + | [[Category: Sandy, J]] | ||
[[Category: Scorsato, V]] | [[Category: Scorsato, V]] | ||
| - | [[Category: | + | [[Category: Smetana, J H.C]] |
| + | [[Category: Protein binding]] | ||
| + | [[Category: Protein binding tip41-like family pp2a]] | ||
Revision as of 16:21, 10 August 2016
Crystal structure of TIPRL, TOR signaling pathway regulator-like, in complex with peptide
| |||||||||||
