5fjv
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of the extracellular domain of alpha2 nicotinic acetylcholine receptor in pentameric assembly== | |
| - | + | <StructureSection load='5fjv' size='340' side='right' caption='[[5fjv]], [[Resolution|resolution]] 3.20Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5fjv]] is a 5 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5FJV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5FJV FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=EPJ:EPIBATIDINE'>EPJ</scene></td></tr> | |
| - | [[ | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5fjv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5fjv OCA], [http://pdbe.org/5fjv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5fjv RCSB], [http://www.ebi.ac.uk/pdbsum/5fjv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5fjv ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/ACHA2_HUMAN ACHA2_HUMAN]] Autosomal dominant nocturnal frontal lobe epilepsy. The disease is caused by mutations affecting the gene represented in this entry. | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/ACHA2_HUMAN ACHA2_HUMAN]] After binding acetylcholine, the AChR responds by an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Chroni-Tzartou, D]] | [[Category: Chroni-Tzartou, D]] | ||
[[Category: Giastas, P]] | [[Category: Giastas, P]] | ||
[[Category: Kouvatsos, N]] | [[Category: Kouvatsos, N]] | ||
| - | [[Category: Tzartos, S | + | [[Category: Tzartos, S J]] |
| + | [[Category: Acetylcholine-binding protein]] | ||
| + | [[Category: Agonist]] | ||
| + | [[Category: Alpha2]] | ||
| + | [[Category: Epibatidine]] | ||
| + | [[Category: Extracellular domain]] | ||
| + | [[Category: Nachr]] | ||
| + | [[Category: Nicotinic acetylcholine receptor]] | ||
Revision as of 16:24, 10 August 2016
Crystal structure of the extracellular domain of alpha2 nicotinic acetylcholine receptor in pentameric assembly
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