5hph

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'''Unreleased structure'''
 
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The entry 5hph is ON HOLD until Paper Publication
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==Structure of TRAP1 fragment==
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<StructureSection load='5hph' size='340' side='right' caption='[[5hph]], [[Resolution|resolution]] 2.43&Aring;' scene=''>
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Authors:
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== Structural highlights ==
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<table><tr><td colspan='2'>[[5hph]] is a 2 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5HPH OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5HPH FirstGlance]. <br>
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Description:
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ANP:PHOSPHOAMINOPHOSPHONIC+ACID-ADENYLATE+ESTER'>ANP</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PO4:PHOSPHATE+ION'>PO4</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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[[Category: Unreleased Structures]]
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5hph FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5hph OCA], [http://pdbe.org/5hph PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5hph RCSB], [http://www.ebi.ac.uk/pdbsum/5hph PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5hph ProSAT]</span></td></tr>
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</table>
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== Function ==
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[[http://www.uniprot.org/uniprot/TRAP1_HUMAN TRAP1_HUMAN]] Chaperone that expresses an ATPase activity. Involved in maintaining mitochondrial function and polarization, most likely through stabilization of mitochondrial complex I. Is a negative regulator of mitochondrial respiration able to modulate the balance between oxidative phosphorylation and aerobic glycolysis. The impact of TRAP1 on mitochondrial respiration is probably mediated by modulation of mitochondrial SRC and inhibition of SDHA.<ref>PMID:23525905</ref> <ref>PMID:23564345</ref> <ref>PMID:23747254</ref>
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== References ==
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<references/>
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__TOC__
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</StructureSection>
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[[Category: Chang, C]]
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[[Category: Lee, S]]
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[[Category: Sung, N]]
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[[Category: Tsai, F T.F]]
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[[Category: Chaperone]]
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[[Category: Hsp90]]
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[[Category: Trap1]]

Revision as of 16:26, 10 August 2016

Structure of TRAP1 fragment

5hph, resolution 2.43Å

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