5ir4
From Proteopedia
(Difference between revisions)
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| - | '''Unreleased structure''' | ||
| - | + | ==Crystal structure of wild-type bacterial lipoxygenase from Pseudomonas aeruginosa PA-LOX with space group C2221 at 1.48 A resolution== | |
| - | + | <StructureSection load='5ir4' size='340' side='right' caption='[[5ir4]], [[Resolution|resolution]] 1.48Å' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5ir4]] is a 1 chain structure. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5IR4 OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5IR4 FirstGlance]. <br> | |
| - | + | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=FE2:FE+(II)+ION'>FE2</scene>, <scene name='pdbligand=GOL:GLYCEROL'>GOL</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene>, <scene name='pdbligand=PEG:DI(HYDROXYETHYL)ETHER'>PEG</scene>, <scene name='pdbligand=ZPE:(2R)-3-{[(S)-(2-AMINOETHOXY)(HYDROXY)PHOSPHORYL]OXY}-2-(TETRADEC-5-ENOYLOXY)PROPYL+(11Z)-OCTADEC-11-ENOATE'>ZPE</scene></td></tr> | |
| - | [[Category: | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5ir4 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5ir4 OCA], [http://pdbe.org/5ir4 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5ir4 RCSB], [http://www.ebi.ac.uk/pdbsum/5ir4 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5ir4 ProSAT]</span></td></tr> |
| + | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/LOXA_PSEAE LOXA_PSEAE]] Converts arachidonic acid to 15S-hydroperoxyeicosatetraenoic acid (HpETE) which is rapidly reduced to hydroxyeicosatetraenoic acid (HETE). Could act on exogenous human-derived substrates to potentially modulate the local inflammatory responses during P.aeruginosa infections.<ref>PMID:14766977</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
| + | [[Category: Banthiya, S]] | ||
| + | [[Category: Kalms, J]] | ||
| + | [[Category: Kuhn, H]] | ||
| + | [[Category: Scheerer, P]] | ||
| + | [[Category: Yoga, E Galemou]] | ||
| + | [[Category: Eicosanoid]] | ||
| + | [[Category: Infectious disease]] | ||
| + | [[Category: Non-heme iron enzyme]] | ||
| + | [[Category: Oxidoreductase]] | ||
| + | [[Category: Protein-phospholipid complex]] | ||
Revision as of 16:26, 10 August 2016
Crystal structure of wild-type bacterial lipoxygenase from Pseudomonas aeruginosa PA-LOX with space group C2221 at 1.48 A resolution
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