5l3l
From Proteopedia
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| - | '''Unreleased structure''' | ||
| - | + | ==D11 bound IGF-II== | |
| - | + | <StructureSection load='5l3l' size='340' side='right' caption='[[5l3l]], [[NMR_Ensembles_of_Models | 20 NMR models]]' scene=''> | |
| - | + | == Structural highlights == | |
| - | + | <table><tr><td colspan='2'>[[5l3l]] is a 1 chain structure. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=5L3L OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5L3L FirstGlance]. <br> | |
| - | + | </td></tr><tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=5l3l FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=5l3l OCA], [http://pdbe.org/5l3l PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=5l3l RCSB], [http://www.ebi.ac.uk/pdbsum/5l3l PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=5l3l ProSAT]</span></td></tr> | |
| - | [[ | + | </table> |
| + | == Disease == | ||
| + | [[http://www.uniprot.org/uniprot/IGF2_HUMAN IGF2_HUMAN]] Epigenetic changes of DNA hypomethylation in IGF2 are a cause of Silver-Russell syndrome (SRS) [MIM:[http://omim.org/entry/180860 180860]]. A clinically heterogeneous condition characterized by severe intrauterine growth retardation, poor postnatal growth, craniofacial features such as a triangular shaped face and a broad forehead, body asymmetry, and a variety of minor malformations. The phenotypic expression changes during childhood and adolescence, with the facial features and asymmetry usually becoming more subtle with age.<ref>PMID:19066168</ref> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IGF2_HUMAN IGF2_HUMAN]] The insulin-like growth factors possess growth-promoting activity. In vitro, they are potent mitogens for cultured cells. IGF-II is influenced by placental lactogen and may play a role in fetal development.<ref>PMID:16912056</ref> Preptin undergoes glucose-mediated co-secretion with insulin, and acts as physiological amplifier of glucose-mediated insulin secretion. Exhibits osteogenic properties by increasing osteoblast mitogenic activity through phosphoactivation of MAPK1 and MAPK3.<ref>PMID:16912056</ref> | ||
| + | == References == | ||
| + | <references/> | ||
| + | __TOC__ | ||
| + | </StructureSection> | ||
[[Category: Hexnerova, R]] | [[Category: Hexnerova, R]] | ||
| + | [[Category: Cell cycle]] | ||
| + | [[Category: Igf-ii]] | ||
Revision as of 16:31, 10 August 2016
D11 bound IGF-II
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