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Ribonucleotide reductase

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{{STRUCTURE_1xjf| PDB=1xjf | SIZE=350| SCENE= |right|CAPTION=Class III ribonucleotide reductase dimer complex with DTP (stick model) and Mg+2 ion (green), [[1xjf]] }}
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{{STRUCTURE_1xjf| PDB=1xjf | SIZE=350| SCENE= |right|CAPTION=Class II ribonucleotide reductase dimer complex with DATP (stick model) and Mg+2 ion (green), [[1xjf]] }}
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== Function ==
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'''Ribonucleotide reductase''' (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides. There are 3 classes of RNR.<br />
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'''Ribonucleotide reductase''' (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides<ref>PMID:16756507</ref>. There are 3 classes of RNR.<br />
* '''Class I RNR''' is a tetramer composed from large (RNR1) and small (RNR2) subunits. Class I RNR is iron-dependent and produces tyrosyl radical. Thimidine triphosphate (TTP) is an effector in the reaction.<br />
* '''Class I RNR''' is a tetramer composed from large (RNR1) and small (RNR2) subunits. Class I RNR is iron-dependent and produces tyrosyl radical. Thimidine triphosphate (TTP) is an effector in the reaction.<br />
* ''' Class II RNR''' reduces ribonucleotide triphosphates using coenzyme B12.<br />
* ''' Class II RNR''' reduces ribonucleotide triphosphates using coenzyme B12.<br />
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**[[1h7b]] – T4RNR (mutant) <br />
**[[1h7b]] – T4RNR (mutant) <br />
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== References ==
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<references/>

Revision as of 06:59, 11 August 2016

Template:STRUCTURE 1xjf

Function

Ribonucleotide reductase (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides[1]. There are 3 classes of RNR.

  • Class I RNR is a tetramer composed from large (RNR1) and small (RNR2) subunits. Class I RNR is iron-dependent and produces tyrosyl radical. Thimidine triphosphate (TTP) is an effector in the reaction.
  • Class II RNR reduces ribonucleotide triphosphates using coenzyme B12.
  • Class III RNR generate glycine radical using S-adenosyl methionine and Fe-S center.

For details on human RNR2 see P53R2.
For mouse RNR see Mouse Ribonucleotide Reductase R2.
For RNR small subunit with nitrotyrosine modification see Nitrotyrosine.

3D Structures of Ribonucleotide reductase

Updated on 11-August-2016

References

  1. ↑ Nordlund P, Reichard P. Ribonucleotide reductases. Annu Rev Biochem. 2006;75:681-706. PMID:16756507 doi:http://dx.doi.org/10.1146/annurev.biochem.75.103004.142443

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Michal Harel, Alexander Berchansky, Joel L. Sussman, Jaime Prilusky

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