1nee
From Proteopedia
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|PDB= 1nee |SIZE=350|CAPTION= <scene name='initialview01'>1nee</scene> | |PDB= 1nee |SIZE=350|CAPTION= <scene name='initialview01'>1nee</scene> | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=ZN:ZINC ION'>ZN</scene> | + | |LIGAND= <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= MTH1769 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=145262 Methanothermobacter thermautotrophicus]) | |GENE= MTH1769 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=145262 Methanothermobacter thermautotrophicus]) | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nee FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nee OCA], [http://www.ebi.ac.uk/pdbsum/1nee PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nee RCSB]</span> | ||
}} | }} | ||
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[[Category: Siddiqui, N.]] | [[Category: Siddiqui, N.]] | ||
[[Category: Trempe, J F.]] | [[Category: Trempe, J F.]] | ||
| - | [[Category: ZN]] | ||
[[Category: mixed alpha-beta structure]] | [[Category: mixed alpha-beta structure]] | ||
[[Category: two domain protein]] | [[Category: two domain protein]] | ||
[[Category: zinc finger]] | [[Category: zinc finger]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:29:13 2008'' |
Revision as of 19:29, 30 March 2008
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| Ligands: | |||||||
| Gene: | MTH1769 (Methanothermobacter thermautotrophicus) | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of archaeal translation factor aIF2beta from Methanobacterium thermoautrophicum
Overview
aIF2 beta is the archaeal homolog of eIF2 beta, a member of the eIF2 heterotrimeric complex, implicated in the delivery of Met-tRNA(i)(Met) to the 40S ribosomal subunit. We have determined the solution structure of the intact beta-subunit of aIF2 from Methanobacterium thermoautotrophicum. aIF2 beta is composed of an unfolded N terminus, a mixed alpha/beta core domain and a C-terminal zinc finger. NMR data shows the two folded domains display restricted mobility with respect to each other. Analysis of the aIF2 gamma structure docked to tRNA allowed the identification of a putative binding site for the beta-subunit in the ternary translation complex. Based on structural similarity and biochemical data, a role for the different secondary structure elements is suggested.
About this Structure
1NEE is a Single protein structure of sequence from Methanothermobacter thermautotrophicus. Full crystallographic information is available from OCA.
Reference
Structure of the archaeal translation initiation factor aIF2 beta from Methanobacterium thermoautotrophicum: implications for translation initiation., Gutierrez P, Osborne MJ, Siddiqui N, Trempe JF, Arrowsmith C, Gehring K, Protein Sci. 2004 Mar;13(3):659-67. PMID:14978306
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