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Ribonucleotide reductase

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{{STRUCTURE_1xjf| PDB=1xjf | SIZE=350| SCENE= |right|CAPTION=Class II ribonucleotide reductase dimer complex with DATP (stick model) and Mg+2 ion (green), [[1xjf]] }}
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{
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<StructureSection load='1xjg' size='350' side='right' caption='Class II ribonucleotide reductase dimer complex with DATP (stick model) and Mg+2 ion (green) (PDB entry [[1xjg]])' scene=''>
== Function ==
== Function ==
'''Ribonucleotide reductase''' (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides<ref>PMID:16756507</ref>. There are 3 classes of RNR.<br />
'''Ribonucleotide reductase''' (RNR) catalyzes the formation of deoxyribonucleotides from ribonucleotides<ref>PMID:16756507</ref>. There are 3 classes of RNR.<br />
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For mouse RNR see [[Mouse Ribonucleotide Reductase R2]].<br />
For mouse RNR see [[Mouse Ribonucleotide Reductase R2]].<br />
For RNR small subunit with nitrotyrosine modification see [[Nitrotyrosine]].
For RNR small subunit with nitrotyrosine modification see [[Nitrotyrosine]].
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== Relevance ==
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RNR inhibitors are studied as therapeutic antiviral, antibacterial and anti-cancer drugs<ref>PMID:21791713</ref>.
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== Structural highlights ==
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<ref>PMID:15475969</ref>
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</StructureSection>
== 3D Structures of Ribonucleotide reductase ==
== 3D Structures of Ribonucleotide reductase ==
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*'''Class II ribonucleotide reductase'''
*'''Class II ribonucleotide reductase'''
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**[[1xjf]] – TmRNR + ATP – ''Thermotoga maritima''<BR />
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**[[1xjf]] – TmRNR + DATP – ''Thermotoga maritima''<BR />
**[[1xjg]] - TmRNR + ATP-UDP<BR />
**[[1xjg]] - TmRNR + ATP-UDP<BR />
**[[1xjj]] - TmRNR + GTP<BR />
**[[1xjj]] - TmRNR + GTP<BR />

Revision as of 07:54, 11 August 2016

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Class II ribonucleotide reductase dimer complex with DATP (stick model) and Mg+2 ion (green) (PDB entry 1xjg)

Drag the structure with the mouse to rotate

3D Structures of Ribonucleotide reductase

Updated on 11-August-2016

References

  1. ↑ Nordlund P, Reichard P. Ribonucleotide reductases. Annu Rev Biochem. 2006;75:681-706. PMID:16756507 doi:http://dx.doi.org/10.1146/annurev.biochem.75.103004.142443
  2. ↑ Munro JB, Silva JC. Ribonucleotide reductase as a target to control apicomplexan diseases. Curr Issues Mol Biol. 2012;14(1):9-26. Epub 2011 Jul 26. PMID:21791713
  3. ↑ Larsson KM, Jordan A, Eliasson R, Reichard P, Logan DT, Nordlund P. Structural mechanism of allosteric substrate specificity regulation in a ribonucleotide reductase. Nat Struct Mol Biol. 2004 Nov;11(11):1142-9. Epub 2004 Oct 10. PMID:15475969 doi:http://dx.doi.org/10.1038/nsmb838

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