2yfv
From Proteopedia
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==THE HETEROTRIMERIC COMPLEX OF KLUYVEROMYCES LACTIS SCM3, CSE4 AND H4== | ==THE HETEROTRIMERIC COMPLEX OF KLUYVEROMYCES LACTIS SCM3, CSE4 AND H4== | ||
<StructureSection load='2yfv' size='340' side='right' caption='[[2yfv]], [[Resolution|resolution]] 2.32Å' scene=''> | <StructureSection load='2yfv' size='340' side='right' caption='[[2yfv]], [[Resolution|resolution]] 2.32Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2yfv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2yfv]] is a 3 chain structure with sequence from [http://en.wikipedia.org/wiki/Candida_sphaerica Candida sphaerica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2YFV OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2YFV FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yfw|2yfw]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[2yfw|2yfw]]</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yfv OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2yfv RCSB], [http://www.ebi.ac.uk/pdbsum/2yfv PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2yfv FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2yfv OCA], [http://pdbe.org/2yfv PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2yfv RCSB], [http://www.ebi.ac.uk/pdbsum/2yfv PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2yfv ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CENPA_KLULA CENPA_KLULA]] Histone H3-like variant which exclusively replaces conventional H3 in the nucleosome core of centromeric chromatin at the inner plate of the kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity). [[http://www.uniprot.org/uniprot/Q6CMU6_KLULA Q6CMU6_KLULA]] Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).[SAAS:SAAS00202799] | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
== Publication Abstract from PubMed == | == Publication Abstract from PubMed == | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2yfv" style="background-color:#fffaf0;"></div> | ||
==See Also== | ==See Also== | ||
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__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Candida sphaerica]] |
[[Category: Cho, U S]] | [[Category: Cho, U S]] | ||
[[Category: Harrison, S C]] | [[Category: Harrison, S C]] | ||
Revision as of 07:56, 11 August 2016
THE HETEROTRIMERIC COMPLEX OF KLUYVEROMYCES LACTIS SCM3, CSE4 AND H4
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