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4izg
From Proteopedia
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==Crystal structure of an enolase (mandelate racemase subgroup) from paracococus denitrificans pd1222 (target nysgrc-012907) with bound cis-4oh-d-proline betaine (product)== | ==Crystal structure of an enolase (mandelate racemase subgroup) from paracococus denitrificans pd1222 (target nysgrc-012907) with bound cis-4oh-d-proline betaine (product)== | ||
<StructureSection load='4izg' size='340' side='right' caption='[[4izg]], [[Resolution|resolution]] 1.70Å' scene=''> | <StructureSection load='4izg' size='340' side='right' caption='[[4izg]], [[Resolution|resolution]] 1.70Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4izg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[4izg]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Pardp Pardp]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4IZG OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4IZG FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4OP:(2S,4S)-2-CARBOXY-4-HYDROXY-1,1-DIMETHYLPYRROLIDINIUM'>4OP</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=4OP:(2S,4S)-2-CARBOXY-4-HYDROXY-1,1-DIMETHYLPYRROLIDINIUM'>4OP</scene>, <scene name='pdbligand=IOD:IODIDE+ION'>IOD</scene>, <scene name='pdbligand=MG:MAGNESIUM+ION'>MG</scene></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4izg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4izg OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4izg RCSB], [http://www.ebi.ac.uk/pdbsum/4izg PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4izg FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4izg OCA], [http://pdbe.org/4izg PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4izg RCSB], [http://www.ebi.ac.uk/pdbsum/4izg PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4izg ProSAT]</span></td></tr> |
</table> | </table> | ||
== Function == | == Function == | ||
| - | [[http://www.uniprot.org/uniprot/ | + | [[http://www.uniprot.org/uniprot/HPBD_PARDP HPBD_PARDP]] Catalyzes the 2-epimerization of trans-4-hydroxy-L-proline betaine (tHyp-B) to cis-4-hydroxy-D-proline betaine (cHyp-B). Is involved in a catabolic pathway that degrades tHyp-B to alpha-ketoglutarate. This pathway would permit the utilization of tHyp-B as a carbon and nitrogen source in the absence of osmotic stress, since tHyp-B functions as an osmolyte and is not catabolized when it is needed as osmoprotectant. Can also catalyze the racemization of L-proline betaine.<ref>PMID:24056934</ref> |
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Pardp]] |
[[Category: Almo, S C]] | [[Category: Almo, S C]] | ||
[[Category: Bhosle, R]] | [[Category: Bhosle, R]] | ||
Revision as of 09:15, 11 August 2016
Crystal structure of an enolase (mandelate racemase subgroup) from paracococus denitrificans pd1222 (target nysgrc-012907) with bound cis-4oh-d-proline betaine (product)
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Categories: Pardp | Almo, S C | Bhosle, R | Bonanno, J B | Chamala, S | Evans, B | Gerlt, J A | Gizzi, A | Hammonds, J | Hillerich, B | Kar, A | LaFleur, J | Love, J | Morisco, L L | Structural genomic | Seidel, R D | Sojitra, S | Stead, M | Toro, R | Vetting, M W | Villigas, G | Wasserman, S R | Betaine racemase | Enolase | Isomerase | Nysgrc | Proline betaine racemease | Psi-biology
