Ribosomal protein S6 kinase
From Proteopedia
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{{STRUCTURE_2z7q| PDB=2z7q | SIZE=300| SCENE=Ribosomal_protein_S6_kinase/Cv/1 |right|CAPTION=Ribosomal protein S6 kinase complex with AMP-PCP and Mg+2 ion (green) [[2z7q]] }} | {{STRUCTURE_2z7q| PDB=2z7q | SIZE=300| SCENE=Ribosomal_protein_S6_kinase/Cv/1 |right|CAPTION=Ribosomal protein S6 kinase complex with AMP-PCP and Mg+2 ion (green) [[2z7q]] }} | ||
| + | == Function == | ||
| + | [[Ribosomal protein S6 kinase]] (RPS6K) regulates RPS6<ref>PMID:22168436</ref>. RPS6K activity controls the ribosome biogenesis transcriptional program. | ||
| - | + | == Relevance == | |
| + | hRPS6K α is over expressed in breast cancer and is associated with poor prognosis<ref>PMID:19085255</ref>. | ||
== 3D Structures of Ribosomal protein S6 kinase == | == 3D Structures of Ribosomal protein S6 kinase == | ||
Revision as of 09:54, 11 August 2016
Contents |
Function
Ribosomal protein S6 kinase (RPS6K) regulates RPS6[1]. RPS6K activity controls the ribosome biogenesis transcriptional program.
Relevance
hRPS6K α is over expressed in breast cancer and is associated with poor prognosis[2].
3D Structures of Ribosomal protein S6 kinase
Updated on 11-August-2016
References
- ↑ Magnuson B, Ekim B, Fingar DC. Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks. Biochem J. 2012 Jan 1;441(1):1-21. doi: 10.1042/BJ20110892. PMID:22168436 doi:http://dx.doi.org/10.1042/BJ20110892
- ↑ Kim D, Akcakanat A, Singh G, Sharma C, Meric-Bernstam F. Regulation and localization of ribosomal protein S6 kinase 1 isoforms. Growth Factors. 2009 Feb;27(1):12-21. doi: 10.1080/08977190802556986. PMID:19085255 doi:http://dx.doi.org/10.1080/08977190802556986
