Ribosomal protein S6 kinase
From Proteopedia
(Difference between revisions)
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== Relevance == | == Relevance == | ||
| - | hRPS6K α is over expressed in breast cancer and is associated with poor prognosis<ref>PMID:19085255</ref>. | + | hRPS6K α is over expressed in breast cancer and is associated with poor prognosis<ref>PMID:19085255</ref>. Inhibitors of RPS6S are studied as potential therapeutic agents for treatment of variety of diseases including diabetes and cancer<ref>PMID:24072592</ref>. |
== 3D Structures of Ribosomal protein S6 kinase == | == 3D Structures of Ribosomal protein S6 kinase == | ||
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*Ribosomal protein S6 kinase α | *Ribosomal protein S6 kinase α | ||
| - | + | **[[3rny]], [[2wnt]] - hRPS6K α−1 C-terminal kinase domain - human<br /> | |
| - | **[[3rny]], [[2wnt]] - hRPS6K α−1 C-terminal kinase domain<br /> | + | |
**[[2qr7]], [[2qr8]] - mRPS6K α−3 C-terminal kinase domain (mutant) - mouse<br /> | **[[2qr7]], [[2qr8]] - mRPS6K α−3 C-terminal kinase domain (mutant) - mouse<br /> | ||
**[[3g51]] - mRPS6K α−3 N-terminal kinase domain<br /> | **[[3g51]] - mRPS6K α−3 N-terminal kinase domain<br /> | ||
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**[[4m8t]], [[4mao]] - mRPS6K α−3 C-terminal kinase domain (mutant) + inhibitor<br /> | **[[4m8t]], [[4mao]] - mRPS6K α−3 C-terminal kinase domain (mutant) + inhibitor<br /> | ||
**[[3kn5]] - hRPS6K α−5 C-terminal kinase domain+AMPPNP<br /> | **[[3kn5]] - hRPS6K α−5 C-terminal kinase domain+AMPPNP<br /> | ||
| + | **[[2z7q]] - hRPS6K α−1 N-terminal kinase domain + AMPPCP<br /> | ||
*Ribosomal protein S6 kinase β | *Ribosomal protein S6 kinase β | ||
Revision as of 10:01, 11 August 2016
Contents |
Function
Ribosomal protein S6 kinase (RPS6K) regulates RPS6[1]. RPS6K activity controls the ribosome biogenesis transcriptional program.
Relevance
hRPS6K α is over expressed in breast cancer and is associated with poor prognosis[2]. Inhibitors of RPS6S are studied as potential therapeutic agents for treatment of variety of diseases including diabetes and cancer[3].
3D Structures of Ribosomal protein S6 kinase
Updated on 11-August-2016
References
- ↑ Magnuson B, Ekim B, Fingar DC. Regulation and function of ribosomal protein S6 kinase (S6K) within mTOR signalling networks. Biochem J. 2012 Jan 1;441(1):1-21. doi: 10.1042/BJ20110892. PMID:22168436 doi:http://dx.doi.org/10.1042/BJ20110892
- ↑ Kim D, Akcakanat A, Singh G, Sharma C, Meric-Bernstam F. Regulation and localization of ribosomal protein S6 kinase 1 isoforms. Growth Factors. 2009 Feb;27(1):12-21. doi: 10.1080/08977190802556986. PMID:19085255 doi:http://dx.doi.org/10.1080/08977190802556986
- ↑ Couty S, Westwood IM, Kalusa A, Cano C, Travers J, Boxall K, Chow CL, Burns S, Schmitt J, Pickard L, Barillari C, McAndrew PC, Clarke PA, Linardopoulos S, Griffin RJ, Aherne GW, Raynaud FI, Workman P, Jones K, van Montfort RL. The discovery of potent ribosomal S6 kinase inhibitors by high-throughput screening and structure-guided drug design. Oncotarget. 2013 Aug 25. PMID:24072592
