4b8w
From Proteopedia
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==Crystal structure of human GDP-L-fucose synthase with bound NADP and GDP, tetragonal crystal form== | ==Crystal structure of human GDP-L-fucose synthase with bound NADP and GDP, tetragonal crystal form== | ||
<StructureSection load='4b8w' size='340' side='right' caption='[[4b8w]], [[Resolution|resolution]] 2.75Å' scene=''> | <StructureSection load='4b8w' size='340' side='right' caption='[[4b8w]], [[Resolution|resolution]] 2.75Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4b8w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[4b8w]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4B8W OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4B8W FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=GDP:GUANOSINE-5-DIPHOSPHATE'>GDP</scene>, <scene name='pdbligand=NAP:NADP+NICOTINAMIDE-ADENINE-DINUCLEOTIDE+PHOSPHATE'>NAP</scene></td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/GDP-L-fucose_synthase GDP-L-fucose synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.271 1.1.1.271] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/GDP-L-fucose_synthase GDP-L-fucose synthase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=1.1.1.271 1.1.1.271] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b8w OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4b8w RCSB], [http://www.ebi.ac.uk/pdbsum/4b8w PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4b8w FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4b8w OCA], [http://pdbe.org/4b8w PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4b8w RCSB], [http://www.ebi.ac.uk/pdbsum/4b8w PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4b8w ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/FCL_HUMAN FCL_HUMAN]] Two step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: GDP-L-fucose synthase]] | [[Category: GDP-L-fucose synthase]] | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Arrowsmith, C H]] | [[Category: Arrowsmith, C H]] | ||
[[Category: Bountra, C]] | [[Category: Bountra, C]] | ||
Revision as of 10:20, 11 August 2016
Crystal structure of human GDP-L-fucose synthase with bound NADP and GDP, tetragonal crystal form
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Categories: GDP-L-fucose synthase | Human | Arrowsmith, C H | Bountra, C | Bunkoczi, G | Carpenter, E | Chaikuat, A | Delft, F Von | Edwards, A | Kavanagh, K | Krojer, T | Oppermann, U | Pike, A | Rojkova, A | Shafqat, N | Vollmar, M | Weigelt, J | Yue, W W | Oxidoreductase
