2x9q
From Proteopedia
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==STRUCTURE OF THE MYCOBACTERIUM TUBERCULOSIS PROTEIN, RV2275, DEMONSTRATES THAT CYCLODIPEPTIDE SYNTHETASES ARE RELATED TO TYPE I TRNA-SYNTHETASES.== | ==STRUCTURE OF THE MYCOBACTERIUM TUBERCULOSIS PROTEIN, RV2275, DEMONSTRATES THAT CYCLODIPEPTIDE SYNTHETASES ARE RELATED TO TYPE I TRNA-SYNTHETASES.== | ||
<StructureSection load='2x9q' size='340' side='right' caption='[[2x9q]], [[Resolution|resolution]] 2.02Å' scene=''> | <StructureSection load='2x9q' size='340' side='right' caption='[[2x9q]], [[Resolution|resolution]] 2.02Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[2x9q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[2x9q]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Myctu Myctu]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2X9Q OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2X9Q FirstGlance]. <br> |
</td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | </td></tr><tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=MSE:SELENOMETHIONINE'>MSE</scene></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x9q OCA], [http://www.rcsb.org/pdb/explore.do?structureId=2x9q RCSB], [http://www.ebi.ac.uk/pdbsum/2x9q PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=2x9q FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=2x9q OCA], [http://pdbe.org/2x9q PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=2x9q RCSB], [http://www.ebi.ac.uk/pdbsum/2x9q PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=2x9q ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/CDTS_MYCTU CDTS_MYCTU]] Involved in the biosynthesis of mycocyclosin. It uses activated amino acids in the form of aminoacyl-tRNAs (aa-tRNAs) as substrates to catalyze the ATP-independent formation of cyclodipeptides which are intermediates in diketopiperazine (DKP) biosynthetic pathways. Catalyzes the formation of cyclo(L-Tyr-L-Tyr) (cYY) from L-tyrosyl-tRNA(Tyr). Can incorporate various nonpolar residues, such as L-phenylalanine, L-leucine, L-tyrosine and L-methionine, and to a much lesser extent L-alanine, into cyclodipeptides. Cyclodipeptides synthesized by Rv2275 always contain L-tyrosine.<ref>PMID:19430487</ref> | ||
== Evolutionary Conservation == | == Evolutionary Conservation == | ||
[[Image:Consurf_key_small.gif|200px|right]] | [[Image:Consurf_key_small.gif|200px|right]] | ||
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<text>to colour the structure by Evolutionary Conservation</text> | <text>to colour the structure by Evolutionary Conservation</text> | ||
</jmolCheckbox> | </jmolCheckbox> | ||
| - | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/ | + | </jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=2x9q ConSurf]. |
<div style="clear:both"></div> | <div style="clear:both"></div> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 2x9q" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Myctu]] |
[[Category: Blanchard, J S]] | [[Category: Blanchard, J S]] | ||
[[Category: Hegde, S S]] | [[Category: Hegde, S S]] | ||
[[Category: Vetting, M W]] | [[Category: Vetting, M W]] | ||
[[Category: Ligase]] | [[Category: Ligase]] | ||
Revision as of 11:10, 11 August 2016
STRUCTURE OF THE MYCOBACTERIUM TUBERCULOSIS PROTEIN, RV2275, DEMONSTRATES THAT CYCLODIPEPTIDE SYNTHETASES ARE RELATED TO TYPE I TRNA-SYNTHETASES.
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