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3opy

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{{Large structure}}
==Crystal structure of Pichia pastoris phosphofructokinase in the T-state==
==Crystal structure of Pichia pastoris phosphofructokinase in the T-state==
<StructureSection load='3opy' size='340' side='right' caption='[[3opy]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
<StructureSection load='3opy' size='340' side='right' caption='[[3opy]], [[Resolution|resolution]] 3.05&Aring;' scene=''>
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=ATP:ADENOSINE-5-TRIPHOSPHATE'>ATP</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-phosphofructokinase 6-phosphofructokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.11 2.7.1.11] </span></td></tr>
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/6-phosphofructokinase 6-phosphofructokinase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=2.7.1.11 2.7.1.11] </span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3opy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3opy OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3opy RCSB], [http://www.ebi.ac.uk/pdbsum/3opy PDBsum]</span></td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3opy FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3opy OCA], [http://pdbe.org/3opy PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3opy RCSB], [http://www.ebi.ac.uk/pdbsum/3opy PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3opy ProSAT]</span></td></tr>
</table>
</table>
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{{Large structure}}
== Function ==
== Function ==
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[[http://www.uniprot.org/uniprot/Q8NJU8_PICPA Q8NJU8_PICPA]] Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.[HAMAP-Rule:MF_03184]<ref>PMID:12125050</ref> [[http://www.uniprot.org/uniprot/A7MAS3_PICPA A7MAS3_PICPA]] Structural subunit of pyrophosphate--fructose 6-phosphate 1-phosphotransferase. Not required for catalytic activity. Fine-tunes allosteric regulation of the ATP-PFK by ATP, fructose 2,6-bisphosphate and AMP.<ref>PMID:17522059</ref> [[http://www.uniprot.org/uniprot/Q8TGA0_PICPA Q8TGA0_PICPA]] Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.[HAMAP-Rule:MF_03184]<ref>PMID:12125050</ref>
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[[http://www.uniprot.org/uniprot/PFKA1_PICPA PFKA1_PICPA]] Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.[HAMAP-Rule:MF_03184]<ref>PMID:12125050</ref> [[http://www.uniprot.org/uniprot/PFKA3_PICPA PFKA3_PICPA]] Structural subunit of pyrophosphate--fructose 6-phosphate 1-phosphotransferase. Not required for catalytic activity. Fine-tunes allosteric regulation of the ATP-PFK by ATP, fructose 2,6-bisphosphate and AMP.<ref>PMID:17522059</ref> [[http://www.uniprot.org/uniprot/PFKA2_PICPA PFKA2_PICPA]] Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.[HAMAP-Rule:MF_03184]<ref>PMID:12125050</ref>
== Evolutionary Conservation ==
== Evolutionary Conservation ==
[[Image:Consurf_key_small.gif|200px|right]]
[[Image:Consurf_key_small.gif|200px|right]]
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<text>to colour the structure by Evolutionary Conservation</text>
<text>to colour the structure by Evolutionary Conservation</text>
</jmolCheckbox>
</jmolCheckbox>
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/chain_selection.php?pdb_ID=2ata ConSurf].
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</jmol>, as determined by [http://consurfdb.tau.ac.il/ ConSurfDB]. You may read the [[Conservation%2C_Evolutionary|explanation]] of the method and the full data available from [http://bental.tau.ac.il/new_ConSurfDB/main_output.php?pdb_ID=3opy ConSurf].
<div style="clear:both"></div>
<div style="clear:both"></div>
<div style="background-color:#fffaf0;">
<div style="background-color:#fffaf0;">
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
</div>
</div>
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<div class="pdbe-citations 3opy" style="background-color:#fffaf0;"></div>
==See Also==
==See Also==

Revision as of 11:17, 11 August 2016

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Crystal structure of Pichia pastoris phosphofructokinase in the T-state

3opy, resolution 3.05Å

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