1nnk
From Proteopedia
| Line 4: | Line 4: | ||
|PDB= 1nnk |SIZE=350|CAPTION= <scene name='initialview01'>1nnk</scene>, resolution 1.85Å | |PDB= 1nnk |SIZE=350|CAPTION= <scene name='initialview01'>1nnk</scene>, resolution 1.85Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=CE2:3-(5-TERT-BUTYL-3-OXIDOISOXAZOL-4-YL)-L-ALANINATE'>CE2</scene>, <scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY=[[1ftj|1FTJ]], [[1ftk|1FTK]], [[1fto|1FTO]], [[1fw0|1FW0]], [[1ftl|1FTL]], [[1gr2|1GR2]], [[1lb8|1LB8]], [[1lb9|1LB9]], [[1lbc|1LBC]], [[1m5e|1M5E]], [[1m5c|1M5C]], [[1m5b|1M5B]], [[1m5f|1M5F]], [[1mm7|1MM7]], [[1mm6|1MM6]], [[1lbb|1LBB]], [[1my4|1MY4]], [[1my3|1MY3]], [[1m5d|1M5D]], [[1ftm|1FTM]], [[1nnp|1NNP]] | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1nnk FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1nnk OCA], [http://www.ebi.ac.uk/pdbsum/1nnk PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1nnk RCSB]</span> | ||
}} | }} | ||
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[[Category: Lunn, M L.]] | [[Category: Lunn, M L.]] | ||
[[Category: Stensbol, T B.]] | [[Category: Stensbol, T B.]] | ||
| - | [[Category: CE2]] | ||
| - | [[Category: CL]] | ||
| - | [[Category: ZN]] | ||
[[Category: agonist complex]] | [[Category: agonist complex]] | ||
[[Category: ionotropic glutamate receptor glur2]] | [[Category: ionotropic glutamate receptor glur2]] | ||
[[Category: ligand-binding core]] | [[Category: ligand-binding core]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:32:51 2008'' |
Revision as of 19:32, 30 March 2008
| |||||||
| , resolution 1.85Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , | ||||||
| Related: | 1FTJ, 1FTK, 1FTO, 1FW0, 1FTL, 1GR2, 1LB8, 1LB9, 1LBC, 1M5E, 1M5C, 1M5B, 1M5F, 1MM7, 1MM6, 1LBB, 1MY4, 1MY3, 1M5D, 1FTM, 1NNP
| ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
X-ray structure of the GluR2 ligand-binding core (S1S2J) in complex with (S)-ATPA at 1.85 A resolution. Crystallization with zinc ions.
Overview
Two X-ray structures of the GluR2 ligand-binding core in complex with (S)-2-amino-3-(5-tert-butyl-3-hydroxy-4-isoxazolyl)propionic acid ((S)-ATPA) have been determined with and without Zn(2+) ions. (S)-ATPA induces a domain closure of ca. 21 degrees compared to the apo form. The tert-butyl moiety of (S)-ATPA is buried in a partially hydrophobic pocket and forces the ligand into the glutamate-like binding mode. The structures provide new insight into the molecular basis of agonist selectivity between AMPA and kainate receptors.
About this Structure
1NNK is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.
Reference
Three-dimensional structure of the ligand-binding core of GluR2 in complex with the agonist (S)-ATPA: implications for receptor subunit selectivity., Lunn ML, Hogner A, Stensbol TB, Gouaux E, Egebjerg J, Kastrup JS, J Med Chem. 2003 Feb 27;46(5):872-5. PMID:12593667
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