3u7k
From Proteopedia
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==Crystal structures of the Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors== | ==Crystal structures of the Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors== | ||
<StructureSection load='3u7k' size='340' side='right' caption='[[3u7k]], [[Resolution|resolution]] 1.90Å' scene=''> | <StructureSection load='3u7k' size='340' side='right' caption='[[3u7k]], [[Resolution|resolution]] 1.90Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[3u7k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[3u7k]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Staac Staac]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=3U7K OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3U7K FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDB:(S)-N-(CYCLOPENTYLMETHYL)-N-(2-(HYDROXYAMINO)-2-OXOETHYL)-2-(3-(2-METHOXYPHENYL)UREIDO)-3,3-DIMETHYLBUTANAMIDE'>MDB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=MDB:(S)-N-(CYCLOPENTYLMETHYL)-N-(2-(HYDROXYAMINO)-2-OXOETHYL)-2-(3-(2-METHOXYPHENYL)UREIDO)-3,3-DIMETHYLBUTANAMIDE'>MDB</scene>, <scene name='pdbligand=ZN:ZINC+ION'>ZN</scene></td></tr> | ||
<tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr> | <tr id='NonStdRes'><td class="sblockLbl"><b>[[Non-Standard_Residue|NonStd Res:]]</b></td><td class="sblockDat"><scene name='pdbligand=CSD:3-SULFINOALANINE'>CSD</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3u7l|3u7l]], [[3u7m|3u7m]], [[3u7n|3u7n]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3u7l|3u7l]], [[3u7m|3u7m]], [[3u7n|3u7n]]</td></tr> | ||
| - | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SACOL1100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id= | + | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">SACOL1100 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=93062 STAAC])</td></tr> |
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/Peptide_deformylase Peptide deformylase], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.88 3.5.1.88] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u7k OCA], [http://www.rcsb.org/pdb/explore.do?structureId=3u7k RCSB], [http://www.ebi.ac.uk/pdbsum/3u7k PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=3u7k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=3u7k OCA], [http://pdbe.org/3u7k PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=3u7k RCSB], [http://www.ebi.ac.uk/pdbsum/3u7k PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=3u7k ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/DEF_STAAC DEF_STAAC]] Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions.[HAMAP-Rule:MF_00163] | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
[[Category: Peptide deformylase]] | [[Category: Peptide deformylase]] | ||
| - | [[Category: | + | [[Category: Staac]] |
[[Category: Kim, K K]] | [[Category: Kim, K K]] | ||
[[Category: Lee, B J]] | [[Category: Lee, B J]] | ||
Revision as of 12:48, 11 August 2016
Crystal structures of the Staphylococcus aureus peptide deformylase in complex with two classes of new inhibitors
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