4j0u
From Proteopedia
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==Crystal structure of IFIT5/ISG58== | ==Crystal structure of IFIT5/ISG58== | ||
<StructureSection load='4j0u' size='340' side='right' caption='[[4j0u]], [[Resolution|resolution]] 1.97Å' scene=''> | <StructureSection load='4j0u' size='340' side='right' caption='[[4j0u]], [[Resolution|resolution]] 1.97Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4j0u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[4j0u]] is a 1 chain structure with sequence from [http://en.wikipedia.org/wiki/Human Human]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4J0U OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4J0U FirstGlance]. <br> |
| - | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IFIT5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 | + | </td></tr><tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">IFIT5 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> |
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j0u OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4j0u RCSB], [http://www.ebi.ac.uk/pdbsum/4j0u PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4j0u FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4j0u OCA], [http://pdbe.org/4j0u PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4j0u RCSB], [http://www.ebi.ac.uk/pdbsum/4j0u PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4j0u ProSAT]</span></td></tr> |
</table> | </table> | ||
| + | == Function == | ||
| + | [[http://www.uniprot.org/uniprot/IFIT5_HUMAN IFIT5_HUMAN]] Interferon-induced RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs. Single-stranded PPP-RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'-triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non-sequence-specific manner. Also recognizes and binds tRNAs.<ref>PMID:23317505</ref> <ref>PMID:23334420</ref> | ||
| + | == References == | ||
| + | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| - | [[Category: | + | [[Category: Human]] |
[[Category: Cheng, G]] | [[Category: Cheng, G]] | ||
[[Category: Crowley, C]] | [[Category: Crowley, C]] | ||
Revision as of 13:04, 11 August 2016
Crystal structure of IFIT5/ISG58
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Categories: Human | Cheng, G | Crowley, C | Feng, F | Li, J | Liang, H | Liu, Y | Lv, Z | Wang, Y E | Yuan, L | Zeng, S | Antiviral | Helix | Ifit5 structure | Rna binding protein
