4jq2
From Proteopedia
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==AKR1C2 complex with sulindac== | ==AKR1C2 complex with sulindac== | ||
<StructureSection load='4jq2' size='340' side='right' caption='[[4jq2]], [[Resolution|resolution]] 1.75Å' scene=''> | <StructureSection load='4jq2' size='340' side='right' caption='[[4jq2]], [[Resolution|resolution]] 1.75Å' scene=''> | ||
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jq1|4jq1]], [[4jq3|4jq3]], [[4jq4|4jq4]], [[4jqa|4jqa]], [[4jtq|4jtq]], [[4jtr|4jtr]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[4jq1|4jq1]], [[4jq3|4jq3]], [[4jq4|4jq4]], [[4jqa|4jqa]], [[4jtq|4jtq]], [[4jtr|4jtr]]</td></tr> | ||
<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AKR1C2, DDH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | <tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">AKR1C2, DDH2 ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=9606 HUMAN])</td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jq2 OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4jq2 RCSB], [http://www.ebi.ac.uk/pdbsum/4jq2 PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4jq2 FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4jq2 OCA], [http://pdbe.org/4jq2 PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4jq2 RCSB], [http://www.ebi.ac.uk/pdbsum/4jq2 PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4jq2 ProSAT]</span></td></tr> |
</table> | </table> | ||
== Disease == | == Disease == | ||
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== Function == | == Function == | ||
[[http://www.uniprot.org/uniprot/AK1C2_HUMAN AK1C2_HUMAN]] Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability.<ref>PMID:8573067</ref> | [[http://www.uniprot.org/uniprot/AK1C2_HUMAN AK1C2_HUMAN]] Works in concert with the 5-alpha/5-beta-steroid reductases to convert steroid hormones into the 3-alpha/5-alpha and 3-alpha/5-beta-tetrahydrosteroids. Catalyzes the inactivation of the most potent androgen 5-alpha-dihydrotestosterone (5-alpha-DHT) to 5-alpha-androstane-3-alpha,17-beta-diol (3-alpha-diol). Has a high bile-binding ability.<ref>PMID:8573067</ref> | ||
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| + | ==See Also== | ||
| + | *[[Hydroxysteroid dehydrogenase|Hydroxysteroid dehydrogenase]] | ||
== References == | == References == | ||
<references/> | <references/> | ||
Revision as of 14:15, 11 August 2016
AKR1C2 complex with sulindac
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