4ddf

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[[Image:4ddf.png|left|200px]]
 
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==Computationally Designed Self-assembling Octahedral Cage protein, O333, Crystallized in space group P4==
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The line below this paragraph, containing "STRUCTURE_4ddf", creates the "Structure Box" on the page.
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<StructureSection load='4ddf' size='340' side='right' caption='[[4ddf]], [[Resolution|resolution]] 3.15&Aring;' scene=''>
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You may change the PDB parameter (which sets the PDB file loaded into the applet)
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== Structural highlights ==
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or the SCENE parameter (which sets the initial scene displayed when the page is loaded),
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<table><tr><td colspan='2'>[[4ddf]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/"bacillus_cholerae-suis"_smith_1894 "bacillus cholerae-suis" smith 1894]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DDF OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4DDF FirstGlance]. <br>
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or leave the SCENE parameter empty for the default display.
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</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=CL:CHLORIDE+ION'>CL</scene>, <scene name='pdbligand=SO4:SULFATE+ION'>SO4</scene></td></tr>
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<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[3vcd|3vcd]], [[3n79|3n79]]</td></tr>
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{{STRUCTURE_4ddf| PDB=4ddf | SCENE= }}
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<tr id='gene'><td class="sblockLbl"><b>[[Gene|Gene:]]</b></td><td class="sblockDat">PduT ([http://www.ncbi.nlm.nih.gov/Taxonomy/Browser/wwwtax.cgi?mode=Info&srchmode=5&id=28901 "Bacillus cholerae-suis" Smith 1894])</td></tr>
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<tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4ddf FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4ddf OCA], [http://pdbe.org/4ddf PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4ddf RCSB], [http://www.ebi.ac.uk/pdbsum/4ddf PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4ddf ProSAT]</span></td></tr>
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</table>
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<div style="background-color:#fffaf0;">
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== Publication Abstract from PubMed ==
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We describe a general computational method for designing proteins that self-assemble to a desired symmetric architecture. Protein building blocks are docked together symmetrically to identify complementary packing arrangements, and low-energy protein-protein interfaces are then designed between the building blocks in order to drive self-assembly. We used trimeric protein building blocks to design a 24-subunit, 13-nm diameter complex with octahedral symmetry and a 12-subunit, 11-nm diameter complex with tetrahedral symmetry. The designed proteins assembled to the desired oligomeric states in solution, and the crystal structures of the complexes revealed that the resulting materials closely match the design models. The method can be used to design a wide variety of self-assembling protein nanomaterials.
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===Computationally Designed Self-assembling Octahedral Cage protein, O333, Crystallized in space group P4===
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Computational design of self-assembling protein nanomaterials with atomic level accuracy.,King NP, Sheffler W, Sawaya MR, Vollmar BS, Sumida JP, Andre I, Gonen T, Yeates TO, Baker D Science. 2012 Jun 1;336(6085):1171-4. PMID:22654060<ref>PMID:22654060</ref>
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From MEDLINE&reg;/PubMed&reg;, a database of the U.S. National Library of Medicine.<br>
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</div>
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The line below this paragraph, {{ABSTRACT_PUBMED_22654060}}, adds the Publication Abstract to the page
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<div class="pdbe-citations 4ddf" style="background-color:#fffaf0;"></div>
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(as it appears on PubMed at http://www.pubmed.gov), where 22654060 is the PubMed ID number.
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== References ==
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<references/>
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{{ABSTRACT_PUBMED_22654060}}
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__TOC__
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</StructureSection>
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==About this Structure==
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[[Category: Bacillus cholerae-suis smith 1894]]
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[[4ddf]] is a 12 chain structure with sequence from [http://en.wikipedia.org/wiki/Salmonella_enterica Salmonella enterica]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4DDF OCA].
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[[Category: Baker, D]]
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[[Category: King, N P]]
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==Reference==
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[[Category: Sawaya, M R]]
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<ref group="xtra">PMID:022654060</ref><references group="xtra"/>
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[[Category: Sheffler, W]]
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[[Category: Salmonella enterica]]
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[[Category: Yeates, T O]]
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[[Category: Baker, D.]]
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[[Category: King, N P.]]
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[[Category: Sawaya, M R.]]
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[[Category: Sheffler, W.]]
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[[Category: Yeates, T O.]]
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[[Category: Electron transport]]
[[Category: Electron transport]]
[[Category: Self assembling octahedral cage design]]
[[Category: Self assembling octahedral cage design]]

Revision as of 15:42, 11 August 2016

Computationally Designed Self-assembling Octahedral Cage protein, O333, Crystallized in space group P4

4ddf, resolution 3.15Å

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