1o0k
From Proteopedia
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|PDB= 1o0k |SIZE=350|CAPTION= <scene name='initialview01'>1o0k</scene>, resolution 1.17Å | |PDB= 1o0k |SIZE=350|CAPTION= <scene name='initialview01'>1o0k</scene>, resolution 1.17Å | ||
|SITE= | |SITE= | ||
| - | |LIGAND= <scene name='pdbligand=DM1:DAUNOMYCIN'>DM1</scene> | + | |LIGAND= <scene name='pdbligand=DG:2'-DEOXYGUANOSINE-5'-MONOPHOSPHATE'>DG</scene>, <scene name='pdbligand=DM1:DAUNOMYCIN'>DM1</scene>, <scene name='pdbligand=DT:THYMIDINE-5'-MONOPHOSPHATE'>DT</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o0k FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o0k OCA], [http://www.ebi.ac.uk/pdbsum/1o0k PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1o0k RCSB]</span> | ||
}} | }} | ||
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[[Category: Pytel, P D.]] | [[Category: Pytel, P D.]] | ||
[[Category: Squire, C J.]] | [[Category: Squire, C J.]] | ||
| - | [[Category: DM1]] | ||
| - | [[Category: NA]] | ||
[[Category: g-4 quadruplex drug complex]] | [[Category: g-4 quadruplex drug complex]] | ||
[[Category: parallel quadruplex]] | [[Category: parallel quadruplex]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:38:05 2008'' |
Revision as of 19:38, 30 March 2008
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| , resolution 1.17Å | |||||||
|---|---|---|---|---|---|---|---|
| Ligands: | , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
Structure of the First Parallel DNA Quadruplex-drug Complex
Overview
The first crystal structure of a drug (daunomycin) bound to a parallel-stranded intermolecular telomeric G4 quadruplex (d(TGGGGT)4) has been determined to high resolution. A planar assemblage of three daunomycin molecules stacks onto the 5' end of the G4 column, with the daunosamine substituents occupying three of the four quadruplex grooves. The surface area of the terminal G-quartet in this parallel DNA quadruplex, presently occupied by three daunomycins, is sufficiently large that it could easily accommodate other potential telomerase inhibitors such as substituted porphyrins or telomestatin.
About this Structure
1O0K is a Protein complex structure of sequences from [1]. Full crystallographic information is available from OCA.
Reference
Structure of the first parallel DNA quadruplex-drug complex., Clark GR, Pytel PD, Squire CJ, Neidle S, J Am Chem Soc. 2003 Apr 9;125(14):4066-7. PMID:12670225
Page seeded by OCA on Sun Mar 30 22:38:05 2008
