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4a6b
From Proteopedia
(Difference between revisions)
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==Stereoselective Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Lactam Based HIV-1 Protease Inhibitors== | ==Stereoselective Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Lactam Based HIV-1 Protease Inhibitors== | ||
<StructureSection load='4a6b' size='340' side='right' caption='[[4a6b]], [[Resolution|resolution]] 1.80Å' scene=''> | <StructureSection load='4a6b' size='340' side='right' caption='[[4a6b]], [[Resolution|resolution]] 1.80Å' scene=''> | ||
== Structural highlights == | == Structural highlights == | ||
| - | <table><tr><td colspan='2'>[[4a6b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/ | + | <table><tr><td colspan='2'>[[4a6b]] is a 2 chain structure with sequence from [http://en.wikipedia.org/wiki/Aids_virus Aids virus]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=4A6B OCA]. For a <b>guided tour on the structure components</b> use [http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4A6B FirstGlance]. <br> |
</td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QG8:METHYL+((S)-1-(2-([1,1-BIPHENYL]-4-YLMETHYL)-2-(3-((3S,4S)-3-BENZYL-4-HYDROXY-1-((1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL)-2-OXOPYRROLIDIN-3-YL)PROPYL)HYDRAZINYL)-3,3-DIMETHYL-1-OXOBUTAN-2-YL)CARBAMATE'>QG8</scene></td></tr> | </td></tr><tr id='ligand'><td class="sblockLbl"><b>[[Ligand|Ligands:]]</b></td><td class="sblockDat"><scene name='pdbligand=QG8:METHYL+((S)-1-(2-([1,1-BIPHENYL]-4-YLMETHYL)-2-(3-((3S,4S)-3-BENZYL-4-HYDROXY-1-((1S,2R)-2-HYDROXY-2,3-DIHYDRO-1H-INDEN-1-YL)-2-OXOPYRROLIDIN-3-YL)PROPYL)HYDRAZINYL)-3,3-DIMETHYL-1-OXOBUTAN-2-YL)CARBAMATE'>QG8</scene></td></tr> | ||
<tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gno|1gno]], [[2cem|2cem]], [[2cej|2cej]], [[1zpa|1zpa]], [[1wbm|1wbm]], [[1wbk|1wbk]], [[4a4q|4a4q]], [[4a6c|4a6c]]</td></tr> | <tr id='related'><td class="sblockLbl"><b>[[Related_structure|Related:]]</b></td><td class="sblockDat">[[1gno|1gno]], [[2cem|2cem]], [[2cej|2cej]], [[1zpa|1zpa]], [[1wbm|1wbm]], [[1wbk|1wbk]], [[4a4q|4a4q]], [[4a6c|4a6c]]</td></tr> | ||
<tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr> | <tr id='activity'><td class="sblockLbl"><b>Activity:</b></td><td class="sblockDat"><span class='plainlinks'>[http://en.wikipedia.org/wiki/HIV-1_retropepsin HIV-1 retropepsin], with EC number [http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.4.23.16 3.4.23.16] </span></td></tr> | ||
| - | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a6b OCA], [http://www.rcsb.org/pdb/explore.do?structureId=4a6b RCSB], [http://www.ebi.ac.uk/pdbsum/4a6b PDBsum]</span></td></tr> | + | <tr id='resources'><td class="sblockLbl"><b>Resources:</b></td><td class="sblockDat"><span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=4a6b FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=4a6b OCA], [http://pdbe.org/4a6b PDBe], [http://www.rcsb.org/pdb/explore.do?structureId=4a6b RCSB], [http://www.ebi.ac.uk/pdbsum/4a6b PDBsum], [http://prosat.h-its.org/prosat/prosatexe?pdbcode=4a6b ProSAT]</span></td></tr> |
</table> | </table> | ||
<div style="background-color:#fffaf0;"> | <div style="background-color:#fffaf0;"> | ||
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine.<br> | ||
</div> | </div> | ||
| + | <div class="pdbe-citations 4a6b" style="background-color:#fffaf0;"></div> | ||
== References == | == References == | ||
<references/> | <references/> | ||
__TOC__ | __TOC__ | ||
</StructureSection> | </StructureSection> | ||
| + | [[Category: Aids virus]] | ||
[[Category: HIV-1 retropepsin]] | [[Category: HIV-1 retropepsin]] | ||
| - | [[Category: Human immunodeficiency virus]] | ||
[[Category: Arvela, R K]] | [[Category: Arvela, R K]] | ||
[[Category: Joshi, A A]] | [[Category: Joshi, A A]] | ||
Revision as of 17:46, 11 August 2016
Stereoselective Synthesis, X-ray Analysis, and Biological Evaluation of a New Class of Lactam Based HIV-1 Protease Inhibitors
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Categories: Aids virus | HIV-1 retropepsin | Arvela, R K | Joshi, A A | Larhed, M | Ohrngren, P | Persson, M | Rosenquist, A | Samuelsson, B B | Trejos, A | Unge, J | Vrang, L | Wallberg, H | Wu, X | Gamma-butyrol-lactam | Hydrolase
