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1o7t
From Proteopedia
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|PDB= 1o7t |SIZE=350|CAPTION= <scene name='initialview01'>1o7t</scene>, resolution 1.65Å | |PDB= 1o7t |SIZE=350|CAPTION= <scene name='initialview01'>1o7t</scene>, resolution 1.65Å | ||
|SITE= <scene name='pdbsite=HF1:Phf+Binding+Site+For+Chain+I'>HF1</scene> | |SITE= <scene name='pdbsite=HF1:Phf+Binding+Site+For+Chain+I'>HF1</scene> | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=HF3:SMALLEST+HF-OXO-PHOSPHATE+CLUSTER+HF3'>HF3</scene>, <scene name='pdbligand=HF5:HF+OXO+CLUSTER+HF5'>HF5</scene>, <scene name='pdbligand=PHF:HF-OXO-PHOSPHATE+CLUSTER+PHF'>PHF</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o7t FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o7t OCA], [http://www.ebi.ac.uk/pdbsum/1o7t PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1o7t RCSB]</span> | ||
}} | }} | ||
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[[Category: Zhong, W.]] | [[Category: Zhong, W.]] | ||
[[Category: Zu, H.]] | [[Category: Zu, H.]] | ||
| - | [[Category: HF3]] | ||
| - | [[Category: HF5]] | ||
| - | [[Category: PHF]] | ||
[[Category: hafnium]] | [[Category: hafnium]] | ||
[[Category: metal-oxo cluster]] | [[Category: metal-oxo cluster]] | ||
[[Category: periplasmic ferric binding protein]] | [[Category: periplasmic ferric binding protein]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:41:06 2008'' |
Revision as of 19:41, 30 March 2008
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| , resolution 1.65Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
METAL NANOCLUSTERS BOUND TO THE FERRIC BINDING PROTEIN FROM NEISSERIA GONORRHOEAE.
Overview
Transferrins transport Fe3+ and other metal ions in mononuclear-binding sites. We present the first evidence that a member of the transferrin superfamily is able to recognize multi-nuclear oxo-metal clusters, small mineral fragments that are the most abundant forms of many metals in the environment. We show that the ferric ion-binding protein from Neisseria gonorrhoeae (nFbp) readily binds clusters of Fe3+, Ti4+, Zr4+ or Hf4+ in solution. The 1.7 A resolution crystal structure of Hf-nFbp reveals three distinct types of clusters in an open, positively charged cleft between two hinged protein domains. A di-tyrosyl cluster nucleation motif (Tyr195-Tyr196) is situated at the bottom of this cleft and binds either a trinuclear oxo-Hf cluster, which is capped by phosphate, or a pentanuclear cluster, which in turn can be capped with phosphate. This first high-resolution structure of a protein-mineral interface suggests a novel metal-uptake mechanism and provides a model for protein-mediated mineralization/dissimilation, which plays a critical role in geochemical processes.
About this Structure
1O7T is a Single protein structure of sequence from Neisseria gonorrhoeae. Full crystallographic information is available from OCA.
Reference
A novel protein-mineral interface., Alexeev D, Zhu H, Guo M, Zhong W, Hunter DJ, Yang W, Campopiano DJ, Sadler PJ, Nat Struct Biol. 2003 Apr;10(4):297-302. PMID:12598891
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