1o9m
From Proteopedia
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|PDB= 1o9m |SIZE=350|CAPTION= <scene name='initialview01'>1o9m</scene>, resolution 2.4Å | |PDB= 1o9m |SIZE=350|CAPTION= <scene name='initialview01'>1o9m</scene>, resolution 2.4Å | ||
|SITE= <scene name='pdbsite=AC1:42b+Binding+Site+For+Chain+B'>AC1</scene> | |SITE= <scene name='pdbsite=AC1:42b+Binding+Site+For+Chain+B'>AC1</scene> | ||
| - | |LIGAND= <scene name='pdbligand=BDG:O-2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSE'>BDG</scene>, <scene name='pdbligand=P24:1-(AMINOETHYL)AMINO-4-AMINOBUTANE'>P24</scene>, <scene name='pdbligand=PA2:PAROMOMYCIN+(RING+2)'>PA2</scene> | + | |LIGAND= <scene name='pdbligand=42B:4-AMINO-2-HYDROXYBUTANOIC+ACID'>42B</scene>, <scene name='pdbligand=A:ADENOSINE-5'-MONOPHOSPHATE'>A</scene>, <scene name='pdbligand=BDG:O-2,6-DIAMINO-2,6-DIDEOXY-ALPHA-D-GLUCOPYRANOSE'>BDG</scene>, <scene name='pdbligand=C:CYTIDINE-5'-MONOPHOSPHATE'>C</scene>, <scene name='pdbligand=G:GUANOSINE-5'-MONOPHOSPHATE'>G</scene>, <scene name='pdbligand=P24:1-(AMINOETHYL)AMINO-4-AMINOBUTANE'>P24</scene>, <scene name='pdbligand=PA2:PAROMOMYCIN+(RING+2)'>PA2</scene>, <scene name='pdbligand=U:URIDINE-5'-MONOPHOSPHATE'>U</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1o9m FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1o9m OCA], [http://www.ebi.ac.uk/pdbsum/1o9m PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1o9m RCSB]</span> | ||
}} | }} | ||
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[[Category: Murray, J B.]] | [[Category: Murray, J B.]] | ||
[[Category: Russell, R.]] | [[Category: Russell, R.]] | ||
| - | [[Category: 42B]] | ||
| - | [[Category: BDG]] | ||
| - | [[Category: P24]] | ||
| - | [[Category: PA2]] | ||
[[Category: a-site]] | [[Category: a-site]] | ||
[[Category: rna-antibiotic interaction]] | [[Category: rna-antibiotic interaction]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:41:56 2008'' |
Revision as of 19:41, 30 March 2008
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| , resolution 2.4Å | |||||||
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| Sites: | |||||||
| Ligands: | , , , , , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
THE COMPLEX OF A NOVEL ANTIBIOTIC WITH THE AMINOACYL SITE OF THE BACTERIAL RIBOSOME REVEALED BY X-RAY CRYSTALLOGRAPHY.
Overview
The ribosome is an important target for aminoglycoside antibiotics; however, the clinical effectiveness of aminoglycosides has diminished due to bacterial resistance mechanisms. Here we report the X-ray structure of a novel synthetic aminoglycoside bound to the A site of the ribosome, its target for manifestation of activity. The structure validates the in silico design paradigms for the antibiotic and reveals the molecular interactions made by this novel antibiotic in prokaryotes.
About this Structure
1O9M is a Single protein structure of sequence from [1]. Full crystallographic information is available from OCA.
Reference
The complex of a designer antibiotic with a model aminoacyl site of the 30S ribosomal subunit revealed by X-ray crystallography., Russell RJ, Murray JB, Lentzen G, Haddad J, Mobashery S, J Am Chem Soc. 2003 Mar 26;125(12):3410-1. PMID:12643685
Page seeded by OCA on Sun Mar 30 22:41:56 2008
