1oan
From Proteopedia
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|PDB= 1oan |SIZE=350|CAPTION= <scene name='initialview01'>1oan</scene>, resolution 2.75Å | |PDB= 1oan |SIZE=350|CAPTION= <scene name='initialview01'>1oan</scene>, resolution 2.75Å | ||
|SITE= <scene name='pdbsite=AC1:Afl+Binding+Site+For+Chain+A'>AC1</scene> | |SITE= <scene name='pdbsite=AC1:Afl+Binding+Site+For+Chain+A'>AC1</scene> | ||
| - | |LIGAND= <scene name='pdbligand= | + | |LIGAND= <scene name='pdbligand=BMA:BETA-D-MANNOSE'>BMA</scene>, <scene name='pdbligand=FUC:ALPHA-L-FUCOSE'>FUC</scene>, <scene name='pdbligand=NA:SODIUM+ION'>NA</scene>, <scene name='pdbligand=NAG:N-ACETYL-D-GLUCOSAMINE'>NAG</scene> |
|ACTIVITY= | |ACTIVITY= | ||
|GENE= | |GENE= | ||
| + | |DOMAIN= | ||
| + | |RELATEDENTRY= | ||
| + | |RESOURCES=<span class='plainlinks'>[http://oca.weizmann.ac.il/oca-docs/fgij/fg.htm?mol=1oan FirstGlance], [http://oca.weizmann.ac.il/oca-bin/ocaids?id=1oan OCA], [http://www.ebi.ac.uk/pdbsum/1oan PDBsum], [http://www.rcsb.org/pdb/explore.do?structureId=1oan RCSB]</span> | ||
}} | }} | ||
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==About this Structure== | ==About this Structure== | ||
| - | 1OAN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/ | + | 1OAN is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Dengue_virus_2 Dengue virus 2]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1OAN OCA]. |
==Reference== | ==Reference== | ||
A ligand-binding pocket in the dengue virus envelope glycoprotein., Modis Y, Ogata S, Clements D, Harrison SC, Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6986-91. Epub 2003 May 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12759475 12759475] | A ligand-binding pocket in the dengue virus envelope glycoprotein., Modis Y, Ogata S, Clements D, Harrison SC, Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6986-91. Epub 2003 May 20. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/12759475 12759475] | ||
| - | [[Category: Dengue virus | + | [[Category: Dengue virus 2]] |
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Harrison, S C.]] | [[Category: Harrison, S C.]] | ||
[[Category: Modis, Y.]] | [[Category: Modis, Y.]] | ||
| - | [[Category: NA]] | ||
| - | [[Category: NAG]] | ||
[[Category: dengue virus]] | [[Category: dengue virus]] | ||
[[Category: flavivirus]] | [[Category: flavivirus]] | ||
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[[Category: membrane fusion]] | [[Category: membrane fusion]] | ||
| - | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Mar 30 22:42:27 2008'' |
Revision as of 19:42, 30 March 2008
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| , resolution 2.75Å | |||||||
|---|---|---|---|---|---|---|---|
| Sites: | |||||||
| Ligands: | , , , | ||||||
| Resources: | FirstGlance, OCA, PDBsum, RCSB | ||||||
| Coordinates: | save as pdb, mmCIF, xml | ||||||
CRYSTAL STRUCTURE OF THE DENGUE 2 VIRUS ENVELOPE PROTEIN
Overview
Dengue virus is an emerging global health threat. Its major envelope glycoprotein, E, mediates viral attachment and entry by membrane fusion. A crystal structure of the soluble ectodomain of E from dengue virus type 2 reveals a hydrophobic pocket lined by residues that influence the pH threshold for fusion. The pocket, which accepts a hydrophobic ligand, opens and closes through a conformational shift in a beta-hairpin at the interface between two domains. These features point to a structural pathway for the fusion-activating transition and suggest a strategy for finding small-molecule inhibitors of dengue and other flaviviruses.
About this Structure
1OAN is a Single protein structure of sequence from Dengue virus 2. Full crystallographic information is available from OCA.
Reference
A ligand-binding pocket in the dengue virus envelope glycoprotein., Modis Y, Ogata S, Clements D, Harrison SC, Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6986-91. Epub 2003 May 20. PMID:12759475
Page seeded by OCA on Sun Mar 30 22:42:27 2008
