Ribosomal protein L19

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{{STRUCTURE_2xg0| PDB=2xg0 | SIZE=300| SCENE=Ribosomal_protein_L19/Cv/1 |right|CAPTION=Ribosomal protein L19 in the 50S subunit ([[2xg0]], chain T) }}
{{STRUCTURE_2xg0| PDB=2xg0 | SIZE=300| SCENE=Ribosomal_protein_L19/Cv/1 |right|CAPTION=Ribosomal protein L19 in the 50S subunit ([[2xg0]], chain T) }}
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== Function ==
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'''Ribosomal protein L19''' (RPL19) is one of the 34 proteins which belong to the <scene name='Ribosomal_protein_L19/Cv/2'>large 50S subunit</scene> of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. RPL19 is located at the interface between the small and large subunits<ref>PMID:19799608</ref>.
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'''Ribosomal protein L19''' (RPL19) is one of the 34 proteins which belong to the <scene name='Ribosomal_protein_L19/Cv/2'>large 50S subunit</scene> of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. RPL19 is located at the interface between the small and large subunits.
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== Relevance ==
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RPL19 is highly expressed in human breast tumors<ref>PMID:8095182</ref>. RPL19 is a prognostic marker for prostate cancer<ref>PMID:16609016</ref>.
== 3D Structures of Ribosomal protein L19 ==
== 3D Structures of Ribosomal protein L19 ==
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[[2ww9]], [[2wwa]] – yRPL19+RPL4+RPL17+RPL25+RPL26+RPL31+RPL34+RPL35+RPL39+25S RRNA+SSH1P+SSS1+SEB2 – yeast - Cryo EM<BR />
[[2ww9]], [[2wwa]] – yRPL19+RPL4+RPL17+RPL25+RPL26+RPL31+RPL34+RPL35+RPL39+25S RRNA+SSH1P+SSS1+SEB2 – yeast - Cryo EM<BR />
[[2wwb]] - wRPL19+RPL4+RPL17+RPL19+RPL25+RPL26+RPL31+RPL35+RPL39+25S RRNA+5.8S RRNA+ dSEBC61 – wheat - Cryo EM<BR />
[[2wwb]] - wRPL19+RPL4+RPL17+RPL19+RPL25+RPL26+RPL31+RPL35+RPL39+25S RRNA+5.8S RRNA+ dSEBC61 – wheat - Cryo EM<BR />
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:23, 14 August 2016

Template:STRUCTURE 2xg0

Contents

Function

Ribosomal protein L19 (RPL19) is one of the 34 proteins which belong to the of the prokaryotic ribosome or to the ca. 49 proteins in the large 60S subunit of the eukaryotic ribosome. RPL19 is located at the interface between the small and large subunits[1].

Relevance

RPL19 is highly expressed in human breast tumors[2]. RPL19 is a prognostic marker for prostate cancer[3].

3D Structures of Ribosomal protein L19

Updated on 14-August-2016

L19 in part of 80S ribosome

2ww9, 2wwa – yRPL19+RPL4+RPL17+RPL25+RPL26+RPL31+RPL34+RPL35+RPL39+25S RRNA+SSH1P+SSS1+SEB2 – yeast - Cryo EM
2wwb - wRPL19+RPL4+RPL17+RPL19+RPL25+RPL26+RPL31+RPL35+RPL39+25S RRNA+5.8S RRNA+ dSEBC61 – wheat - Cryo EM

References

  1. ↑ Kuroda K, Takenoyama M, Baba T, Shigematsu Y, Shiota H, Ichiki Y, Yasuda M, Uramoto H, Hanagiri T, Yasumoto K. Identification of ribosomal protein L19 as a novel tumor antigen recognized by autologous cytotoxic T lymphocytes in lung adenocarcinoma. Cancer Sci. 2010 Jan;101(1):46-53. doi: 10.1111/j.1349-7006.2009.01351.x. Epub, 2009 Sep 9. PMID:19799608 doi:http://dx.doi.org/10.1111/j.1349-7006.2009.01351.x
  2. ↑ Henry JL, Coggin DL, King CR. High-level expression of the ribosomal protein L19 in human breast tumors that overexpress erbB-2. Cancer Res. 1993 Mar 15;53(6):1403-8. PMID:8095182
  3. ↑ Bee A, Ke Y, Forootan S, Lin K, Beesley C, Forrest SE, Foster CS. Ribosomal protein l19 is a prognostic marker for human prostate cancer. Clin Cancer Res. 2006 Apr 1;12(7 Pt 1):2061-5. PMID:16609016 doi:http://dx.doi.org/10.1158/1078-0432.CCR-05-2445

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Michal Harel, Alexander Berchansky, Joel L. Sussman

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