Ribosomal protein P2

From Proteopedia

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-==P2 in the 60S subunit==
 [[2jdl]] - hRPLP2 peptide + ribosome inactivating protein trichosanthin – human<br />

Revision as of 09:30, 15 August 2016

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Structure of Ribosomal protein P2 beta (PDB entry 3u5i, chain s)

Show:Asymmetric Unit Biological Assembly

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1 Function
2 Relevance
3 3D Structures of ribosomal protein P2
4 References

Function

Ribosomal protein P2 (RPLP2) is one of the 3 phosphoproteins in the large 60S subunit of the eukaryotic ribosome. RPLP2 plays an important role in the elongation step of protein synthesis^[1]. RPLP2 makes a heterodimer with dimers of RPLP1.

Relevance

Antisense RPLP2 technology has potential to slow growth of cancer cells^[2].

3D Structures of ribosomal protein P2

Updated on 15-August-2016

2jdl - hRPLP2 peptide + ribosome inactivating protein trichosanthin – human

2lbf – hRPLP2 + RPLP1 dimerization domain – NMR
2w1o – hRPLP2 dimerization domain – NMR
4beh – hRPLP2 + RPLP1 – NMR

References

↑ Furukawa T, Uchiumi T, Tokunaga R, Taketani S. Ribosomal protein P2, a novel iron-binding protein. Arch Biochem Biophys. 1992 Oct;298(1):182-6. PMID:1524426
↑ Gardner-Thorpe J, Ito H, Ashley SW, Whang EE. Ribosomal protein P2: a potential molecular target for antisense therapy of human malignancies. Anticancer Res. 2003 Nov-Dec;23(6C):4549-60. PMID:14981896