Ribosome inactivating protein

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
<StructureSection load='3u70' size='340' side='right' caption='Glycosylated type 1 ribosome inactivating protein from bitter gourd complex with adenine and glycerol (PDB code [[3u70]])' scene=''>
+
<StructureSection load='1qci' size='340' side='right' caption='Ribosome inactivating protein from pokeweed complex with adenine (PDB code [[1qci]])' scene=''>
-
'''Ribosome inactivating protein''' (RIP) is a bacterial or plant toxin which inhibits protein synthesis. RIP inactivates the ribosomal 60S subunit by N-glycosidic cleavage which results in releasing a specific adenine from 28S rRNA. Type 1 RIP has a single chain, while type 2 RIP has two chains. Enhanced expression of RIP in plants confers an increased resistance to virus, fungi, insects, drought and salinity.
+
-
 
+
== Function ==
== Function ==
-
 
+
'''Ribosome inactivating protein''' (RIP) is a bacterial or plant toxin which inhibits protein synthesis. RIP inactivates the ribosomal 60S subunit by N-glycosidic cleavage which results in releasing a specific adenine from 28S rRNA<ref>PMID:3510899</ref>. '''Type 1 RIP''' have a single chain, while '''type 2 RIP''' (i.e., ricin, ebulin and nigrin) have two chains. '''Momorcharin''' is a RIP isolated from several plants<ref>PMID:23777339</ref>.
-
== Disease ==
+
== Relevance ==
== Relevance ==
-
 
+
RIP is being investigated as an immunotoxin for cancer treatment. Besides the anti-tumor activity of RIP, it was shown to have antiviral, antifungal, insecticidal, ribonuclease and deoxyribonuclease activities. Enhanced expression of RIP in plants confers an increased resistance to virus, fungi, insects, drought and salinity. α-momorcharin has potent inhibitory effect on some cancer cells<ref>PMID:8026716</ref>.
-
RIP is being investigated as an immunotoxin for cancer treatment. Besides the anti-tumor activity of RIP, it was shown to have antiviral, antifungal, insecticidal, ribonuclease and deoxyribonuclease activities.
+
== Structural highlights ==
== Structural highlights ==
-
 
+
The active site of pokeweed RIP contains adenine<ref>PMID:10493577</ref>.
</StructureSection>
</StructureSection>

Revision as of 08:20, 17 August 2016

Ribosome inactivating protein from pokeweed complex with adenine (PDB code 1qci)

Drag the structure with the mouse to rotate

3D Structures of ribosome inactivating protein

Updated on 17-August-2016

References

  1. ↑ Stirpe F, Barbieri L. Ribosome-inactivating proteins up to date. FEBS Lett. 1986 Jan 20;195(1-2):1-8. PMID:3510899
  2. ↑ Wang S, Zheng Y, Yan J, Zhu Z, Wu Z, Ding Y. Alpha-momorcharin: a ribosome-inactivating protein from Momordica charantia, possessing DNA cleavage properties. Protein Pept Lett. 2013 Nov;20(11):1257-63. PMID:23777339
  3. ↑ Ng TB, Liu WK, Sze SF, Yeung HW. Action of alpha-momorcharin, a ribosome inactivating protein, on cultured tumor cell lines. Gen Pharmacol. 1994 Jan;25(1):75-7. PMID:8026716
  4. ↑ Kurinov IV, Myers DE, Irvin JD, Uckun FM. X-ray crystallographic analysis of the structural basis for the interactions of pokeweed antiviral protein with its active site inhibitor and ribosomal RNA substrate analogs. Protein Sci. 1999 Sep;8(9):1765-72. PMID:10493577

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky, Joel L. Sussman

Retrieved from "http://52.214.119.220/wiki/index.php/Ribosome_inactivating_protein"
Personal tools