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RmlC
From Proteopedia
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<StructureSection load='2ixc' size='340' side='right' caption='Structure of RmlC complex with dTPD-rhamnose (PDB code [[2ixc]]).' scene=''> | <StructureSection load='2ixc' size='340' side='right' caption='Structure of RmlC complex with dTPD-rhamnose (PDB code [[2ixc]]).' scene=''> | ||
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| - | '''RmlC''' is an enzyme of the dTPD-rhamnose pathway. Deoxy-thymidine diphosphate (dTDP)-L-rhamnose is the precursor of L-rhamnose. L-rhamnose is a sugar component of microbial cell wall and is absent in human. | ||
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== Function == | == Function == | ||
| + | '''RmlC''' is an enzyme of the dTPD-rhamnose pathway. Deoxy-thymidine diphosphate (dTDP)-L-rhamnose is the precursor of L-rhamnose. L-rhamnose is a sugar component of microbial cell wall and is absent in human<ref>PMID:10802738</ref>. | ||
== Disease == | == Disease == | ||
== Relevance == | == Relevance == | ||
| - | + | Inhibitors of RmlC can serve as potential antimicrobial drugs<ref>PMID:15103135</ref>. | |
| - | Inhibitors of RmlC can serve as potential antimicrobial drugs. | + | |
== Structural highlights == | == Structural highlights == | ||
Revision as of 09:44, 17 August 2016
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3D structures of RmlC
Updated on 17-August-2016
References
- ↑ Giraud MF, Leonard GA, Field RA, Berlind C, Naismith JH. RmlC, the third enzyme of dTDP-L-rhamnose pathway, is a new class of epimerase. Nat Struct Biol. 2000 May;7(5):398-402. PMID:10802738 doi:10.1038/75178
- ↑ Kantardjieff KA, Kim CY, Naranjo C, Waldo GS, Lekin T, Segelke BW, Zemla A, Park MS, Terwilliger TC, Rupp B. Mycobacterium tuberculosis RmlC epimerase (Rv3465): a promising drug-target structure in the rhamnose pathway. Acta Crystallogr D Biol Crystallogr. 2004 May;60(Pt 5):895-902. Epub 2004, Apr 21. PMID:15103135 doi:10.1107/S0907444904005323
