Methionine adenosyltransferase
From Proteopedia
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| - | {{STRUCTURE_1mxb| PDB=1mxb | SIZE=400| SCENE= |right| CAPTION=Monomer of the dimeric E. coli S-adenosylmethionine synthetase complex with phosphate, ADP (stick model), Mg+2 (green) and K+ (purple) ions, [[1mxb]] }} | ||
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| - | '''S-adenosylmethionine synthetase''' (MAT) catalyzes the conversion of methionine and ATP to S-adenosylmethionine (AdoMet), pyrophosphate (PPi) and orthophosphate (Pi). AdoMet is a methyl donor. The catalytic entity of MAT is a dimer. MAT cofactors are Mg+2 (or Co+2) and K+ ions. | ||
| + | <StructureSection load='1o9t' size='350' side='right' caption='Monomer of the dimeric rat S-adenosylmethionine synthetase complex with methionine, phosphate, ATP (stick model), Mg+2 (green) and K+ (purple) ions (PDB entry [[1o9t]])' scene=''> | ||
| + | == Function == | ||
| + | '''S-adenosylmethionine synthetase''' (MAT) catalyzes the conversion of methionine and ATP to S-adenosylmethionine (AdoMet), pyrophosphate (PPi) and orthophosphate (Pi). AdoMet is a methyl donor. The catalytic entity of MAT is a dimer. MAT cofactors are Mg+2 (or Co+2) and K+ ions. | ||
| + | |||
| + | == Structural highlights == | ||
| + | The active site of MAT is located at the dimer interface<ref>PMID:12888348</ref>. | ||
| + | </StructureSection> | ||
==3D structures of S-adenosylmethionine synthetase== | ==3D structures of S-adenosylmethionine synthetase== | ||
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**[[2ydx]] – MAT + resveratrol + NADP + Ca + ADP derivative | **[[2ydx]] – MAT + resveratrol + NADP + Ca + ADP derivative | ||
}} | }} | ||
| + | == References == | ||
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 09:32, 22 August 2016
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3D structures of S-adenosylmethionine synthetase
22-August-2016
References
- ↑ Gonzalez B, Pajares MA, Hermoso JA, Guillerm D, Guillerm G, Sanz-Aparicio J. Crystal structures of methionine adenosyltransferase complexed with substrates and products reveal the methionine-ATP recognition and give insights into the catalytic mechanism. J Mol Biol. 2003 Aug 8;331(2):407-16. PMID:12888348
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