Ribozyme
From Proteopedia
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*'''Hairpin RZ''' and '''hammerhead RZ''' are named based on their shape<ref>PMID:9849614</ref>.<br /> | *'''Hairpin RZ''' and '''hammerhead RZ''' are named based on their shape<ref>PMID:9849614</ref>.<br /> | ||
*'''Group I intron''' catalyzes its own selfish splicing<ref>PMID:2197983</ref>. | *'''Group I intron''' catalyzes its own selfish splicing<ref>PMID:2197983</ref>. | ||
| - | * Comparative genomic analysis revealed '''Twister''', ''Twister sister''', ''Hatchet''', and ''Pistol''' <ref>PMID:24240507</ref><ref>PMID:26167874 </ref>. | + | * Comparative genomic analysis revealed '''Twister''', '''Twister sister''', '''Hatchet''', and '''Pistol''' <ref>PMID:24240507</ref><ref>PMID:26167874 </ref>. |
Revision as of 17:32, 22 August 2016
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Ribozyme (RZ) is an RNA molecule which catalyzes a chemical reaction[1].
- Glucosamine-6-phosphate activated RZ (glmS RZ) is a RZ and a riboswitch which regulates genes in response to metabolites.
- Leadzyme is a small, artificially-made RZ which can cleave RNA in the presence of lead. For more details on leadzyme see Student Projects for UMass Chemistry 423 Spring 2012-10.
- Hairpin RZ and hammerhead RZ are named based on their shape[2].
- Group I intron catalyzes its own selfish splicing[3].
- Comparative genomic analysis revealed Twister, Twister sister, Hatchet, and Pistol [4][5].
Articles in Proteopedia concerning ribozymes include:
- Azoarcus group I intron
- Kink-turn motif
- Ribosome
- The Large Ribosomal Subunit
- Hairpin Ribozyme
- Human CPEB3 ribozyme's P4 domain
To view automatically seeded indices concerning ribozymes, see:
- Ribozyme
- Catalytic RNA
- GlmS
- Hammerhead
- Hairpin
- Hepatitis delta virus
- Twister
- Twister sister
- Hatchet
- Pistol
- Group I intron
- Varkud satellite
3D Structures of Ribozymes
Updated on 22-August-2016
References
- ↑ Tang J, Breaker RR. Rational design of allosteric ribozymes. Chem Biol. 1997 Jun;4(6):453-9. PMID:9224568
- ↑ Amarzguioui M, Prydz H. Hammerhead ribozyme design and application. Cell Mol Life Sci. 1998 Nov;54(11):1175-202. PMID:9849614 doi:http://dx.doi.org/10.1007/s000180050247
- ↑ Cech TR. Self-splicing of group I introns. Annu Rev Biochem. 1990;59:543-68. PMID:2197983 doi:http://dx.doi.org/10.1146/annurev.bi.59.070190.002551
- ↑ Roth A, Weinberg Z, Chen AG, Kim PB, Ames TD, Breaker RR. A widespread self-cleaving ribozyme class is revealed by bioinformatics. Nat Chem Biol. 2014 Jan;10(1):56-60. doi: 10.1038/nchembio.1386. Epub 2013 Nov, 17. PMID:24240507 doi:http://dx.doi.org/10.1038/nchembio.1386
- ↑ Weinberg Z, Kim PB, Chen TH, Li S, Harris KA, Lunse CE, Breaker RR. New classes of self-cleaving ribozymes revealed by comparative genomics analysis. Nat Chem Biol. 2015 Aug;11(8):606-10. doi: 10.1038/nchembio.1846. Epub 2015 Jul, 13. PMID:26167874 doi:http://dx.doi.org/10.1038/nchembio.1846
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