Semaphorin

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{{STRUCTURE_3nvn| PDB=3nvn | SIZE=400| SCENE= |right|CAPTION=Glycosylated human semaphorin 7A (grey) complex with plexin-C1 (green) and Ca+2 ion (green), [[3nvn]] }}
{{STRUCTURE_3nvn| PDB=3nvn | SIZE=400| SCENE= |right|CAPTION=Glycosylated human semaphorin 7A (grey) complex with plexin-C1 (green) and Ca+2 ion (green), [[3nvn]] }}
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== Function ==
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'''Semaphorin''' (SEMA) are membrane proteins which act as axonal growth guidance molecules. SEMA act as short-range inhibitory signal. There are 8 classes of SEMA numbered 1 to 7 and V (viral). Each class has several subgroups which share similar characteristics.
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'''Semaphorin''' (SEMA) are membrane proteins which act as axonal growth guidance molecules. SEMA act as short-range inhibitory signal<ref>PMID:10934324</ref>. There are 8 classes of SEMA numbered 1 to 7 and V (viral). Each class has several subgroups which share similar characteristics.
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== Relevance ==
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SEMAs ar implicated in a number of developmental, psychiatric and neurodegenerative disorders<ref>PMID:19541473</ref>. SEMA 3A is a marker for disease activity of systemic lupus erythematosus<ref>PMID:22875653</ref>.
==3D structures of semaphorin==
==3D structures of semaphorin==
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**[[3nvn]], [[3nvq]] – hSEMA 7A + plexin-C1
**[[3nvn]], [[3nvq]] – hSEMA 7A + plexin-C1
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}}
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 08:28, 24 August 2016

Template:STRUCTURE 3nvn

Contents

Function

Semaphorin (SEMA) are membrane proteins which act as axonal growth guidance molecules. SEMA act as short-range inhibitory signal[1]. There are 8 classes of SEMA numbered 1 to 7 and V (viral). Each class has several subgroups which share similar characteristics.

Relevance

SEMAs ar implicated in a number of developmental, psychiatric and neurodegenerative disorders[2]. SEMA 3A is a marker for disease activity of systemic lupus erythematosus[3].

3D structures of semaphorin

24-August-2016

References

  1. ↑ Nakamura F, Kalb RG, Strittmatter SM. Molecular basis of semaphorin-mediated axon guidance. J Neurobiol. 2000 Aug;44(2):219-29. PMID:10934324
  2. ↑ Pasterkamp RJ, Giger RJ. Semaphorin function in neural plasticity and disease. Curr Opin Neurobiol. 2009 Jun;19(3):263-74. doi: 10.1016/j.conb.2009.06.001. Epub, 2009 Jun 21. PMID:19541473 doi:http://dx.doi.org/10.1016/j.conb.2009.06.001
  3. ↑ Vadasz Z, Toubi E. Semaphorin 3A - a marker for disease activity and a potential putative disease-modifying treatment in systemic lupus erythematosus. Lupus. 2012 Oct;21(12):1266-70. Epub 2012 Aug 8. PMID:22875653 doi:http://dx.doi.org/10.1177/0961203312456753

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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