Semaphorin

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== Function ==
== Function ==
'''Semaphorin''' (SEMA) are membrane proteins which act as axonal growth guidance molecules. SEMA act as short-range inhibitory signal<ref>PMID:10934324</ref>. There are 8 classes of SEMA numbered 1 to 7 and V (viral). Each class has several subgroups which share similar characteristics.
'''Semaphorin''' (SEMA) are membrane proteins which act as axonal growth guidance molecules. SEMA act as short-range inhibitory signal<ref>PMID:10934324</ref>. There are 8 classes of SEMA numbered 1 to 7 and V (viral). Each class has several subgroups which share similar characteristics.
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*'''Semaphorin 3''' is needed for normal patterning and growth of nerves, bones and heart<ref>PMID:8849723</ref>.<br />
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*'''Semaphorin 4D''' acts through its receptor to tip the balance of bone homeostasis toward resorption <ref>PMID:26910109</ref>.<br />
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*'''Semaphorin 7A''' promotes axon growth through integrins and MAPKs <ref>PMID:12879062</ref>.<br />
== Relevance ==
== Relevance ==

Revision as of 08:39, 24 August 2016

Template:STRUCTURE 3nvn

Contents

Function

Semaphorin (SEMA) are membrane proteins which act as axonal growth guidance molecules. SEMA act as short-range inhibitory signal[1]. There are 8 classes of SEMA numbered 1 to 7 and V (viral). Each class has several subgroups which share similar characteristics.

  • Semaphorin 3 is needed for normal patterning and growth of nerves, bones and heart[2].
  • Semaphorin 4D acts through its receptor to tip the balance of bone homeostasis toward resorption [3].
  • Semaphorin 7A promotes axon growth through integrins and MAPKs [4].

Relevance

SEMAs ar implicated in a number of developmental, psychiatric and neurodegenerative disorders[5]. SEMA 3A is a marker for disease activity of systemic lupus erythematosus[6].

3D structures of semaphorin

24-August-2016

References

  1. ↑ Nakamura F, Kalb RG, Strittmatter SM. Molecular basis of semaphorin-mediated axon guidance. J Neurobiol. 2000 Aug;44(2):219-29. PMID:10934324
  2. ↑ Behar O, Golden JA, Mashimo H, Schoen FJ, Fishman MC. Semaphorin III is needed for normal patterning and growth of nerves, bones and heart. Nature. 1996 Oct 10;383(6600):525-8. PMID:8849723 doi:http://dx.doi.org/10.1038/383525a0
  3. ↑ Yang YH, Buhamrah A, Schneider A, Lin YL, Zhou H, Bugshan A, Basile JR. Semaphorin 4D Promotes Skeletal Metastasis in Breast Cancer. PLoS One. 2016 Feb 24;11(2):e0150151. doi: 10.1371/journal.pone.0150151., eCollection 2016. PMID:26910109 doi:http://dx.doi.org/10.1371/journal.pone.0150151
  4. ↑ Pasterkamp RJ, Peschon JJ, Spriggs MK, Kolodkin AL. Semaphorin 7A promotes axon outgrowth through integrins and MAPKs. Nature. 2003 Jul 24;424(6947):398-405. PMID:12879062 doi:http://dx.doi.org/10.1038/nature01790
  5. ↑ Pasterkamp RJ, Giger RJ. Semaphorin function in neural plasticity and disease. Curr Opin Neurobiol. 2009 Jun;19(3):263-74. doi: 10.1016/j.conb.2009.06.001. Epub, 2009 Jun 21. PMID:19541473 doi:http://dx.doi.org/10.1016/j.conb.2009.06.001
  6. ↑ Vadasz Z, Toubi E. Semaphorin 3A - a marker for disease activity and a potential putative disease-modifying treatment in systemic lupus erythematosus. Lupus. 2012 Oct;21(12):1266-70. Epub 2012 Aug 8. PMID:22875653 doi:http://dx.doi.org/10.1177/0961203312456753

Proteopedia Page Contributors and Editors (what is this?)

Michal Harel, Alexander Berchansky

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