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Sentrin-specific protease

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'''Sentrin-specific protease''' 1 (Senp1), Senp2, Senp7, Senp8 catalyze the processing of SUM1, SUMO2 and SUMO3 to their mature forms and deconjugate these proteins from their target proteins. Senp’s hydrolyze a peptide bond in the C-terminal of SUMO propeptide.
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'''Sentrin-specific protease''' 1 (Senp1), Senp2, Senp7, Senp8 catalyze the processing of SUM1, SUMO2 and SUMO3 to their mature forms and deconjugate these proteins from their target proteins. Senp’s hydrolyze a peptide bond in the C-terminal of SUMO propeptide<ref>PMID:24586832</ref>.
</StructureSection>
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**[[2bkq]] – hSenp8 <br />
**[[2bkq]] – hSenp8 <br />
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== References ==
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<references/>
[[Category:Topic Page]]
[[Category:Topic Page]]

Revision as of 09:19, 24 August 2016

Structure of human Senp1 catalytic domain (grey) complex with SUMO1 (green) and RanGAP C terminal (pink) (PDB entry 2iy0)

Drag the structure with the mouse to rotate

3D structures of sentrin-specific protease

Updated on 24-August-2016

References

  1. Lee WP, Jena S, Doherty D, Ventakesh J, Schimdt J, Furmick J, Widener T, Lemau J, Jurutka PW, Thompson PD. Sentrin/SUMO specific proteases as novel tissue-selective modulators of vitamin D receptor-mediated signaling. PLoS One. 2014 Feb 20;9(2):e89506. doi: 10.1371/journal.pone.0089506. eCollection, 2014. PMID:24586832 doi:http://dx.doi.org/10.1371/journal.pone.0089506

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Michal Harel, Alexander Berchansky

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