Serpin
From Proteopedia
(Difference between revisions)
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<StructureSection load='3ndd' size='400' side='right' caption='Structure of cleaved human serpin A1. Residues 46-382 (grey), residues 383-418 (green). (PDB entry [[3ndd]])' scene=''> | <StructureSection load='3ndd' size='400' side='right' caption='Structure of cleaved human serpin A1. Residues 46-382 (grey), residues 383-418 (green). (PDB entry [[3ndd]])' scene=''> | ||
| - | + | == Function == | |
'''Serpin or serine protease inhibitor''' (Ser) are protease inhibitors.<br /> | '''Serpin or serine protease inhibitor''' (Ser) are protease inhibitors.<br /> | ||
* Ser C1 is [[Antithrombin]].<br /> | * Ser C1 is [[Antithrombin]].<br /> | ||
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* Ser A8 is angiotensinogen. <br /> | * Ser A8 is angiotensinogen. <br /> | ||
* Ser A7 is a thyroxine-binding globulin.<br /> | * Ser A7 is a thyroxine-binding globulin.<br /> | ||
| - | * Ser B1 is leukocyte elastase inhibitor.<br /> | + | * Ser B1 is leukocyte elastase inhibitor<ref>PMID:26701651</ref>.<br /> |
| - | * Ser B3 is squamos cell carcinoma antigen 1. <br /> | + | * Ser B3 is squamos cell carcinoma antigen 1<ref>PMID:20527027</ref>. <br /> |
| - | * Ser B5 is Maspin.<br /> | + | * Ser B5 is Maspin<ref>PMID:11309327</ref>.<br /> |
| - | * Ser crmA is cysteine and serine proteinase inhibitor.<br /> | + | * Ser crmA is cysteine and serine proteinase inhibitor<ref>PMID:9065443</ref>.<br /> |
* Ser I1 is neuroserpin. <br /> | * Ser I1 is neuroserpin. <br /> | ||
* Ser A10 is protein Z-related protease inhibitor. <br /> | * Ser A10 is protein Z-related protease inhibitor. <br /> | ||
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* Ser A3 is α 1-antichymotrypsin.<br /> | * Ser A3 is α 1-antichymotrypsin.<br /> | ||
* Ser E1 is [[Plasminogen activator inhibitor]]. | * Ser E1 is [[Plasminogen activator inhibitor]]. | ||
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| + | == Disease == | ||
| + | Mutation in Ser A7 causes partial thyroxine-binding globulin deficiency<ref>PMID:24356794</ref>. Ser B3 may contribute to tumor cell resistance to anti-neoplastic drugs<ref>PMID:25332258</ref>. Ser A3 promotes growth of endometrial cancer cells <ref>PMID:24817931</ref>. | ||
</StructureSection> | </StructureSection> | ||
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}} | }} | ||
| - | + | == References == | |
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:20, 28 August 2016
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3D structures of serpin
Updated on 28-August-2016
References
- ↑ El Ouaamari A, Dirice E, Gedeon N, Hu J, Zhou JY, Shirakawa J, Hou L, Goodman J, Karampelias C, Qiang G, Boucher J, Martinez R, Gritsenko MA, De Jesus DF, Kahraman S, Bhatt S, Smith RD, Beer HD, Jungtrakoon P, Gong Y, Goldfine AB, Liew CW, Doria A, Andersson O, Qian WJ, Remold-O'Donnell E, Kulkarni RN. SerpinB1 Promotes Pancreatic beta Cell Proliferation. Cell Metab. 2016 Jan 12;23(1):194-205. doi: 10.1016/j.cmet.2015.12.001. Epub 2015, Dec 15. PMID:26701651 doi:http://dx.doi.org/10.1016/j.cmet.2015.12.001
- ↑ Quarta S, Vidalino L, Turato C, Ruvoletto M, Calabrese F, Valente M, Cannito S, Fassina G, Parola M, Gatta A, Pontisso P. SERPINB3 induces epithelial-mesenchymal transition. J Pathol. 2010 Jul;221(3):343-56. doi: 10.1002/path.2708. PMID:20527027 doi:http://dx.doi.org/10.1002/path.2708
- ↑ Maass N, Hojo T, Ueding M, Luttges J, Kloppel G, Jonat W, Nagasaki K. Expression of the tumor suppressor gene Maspin in human pancreatic cancers. Clin Cancer Res. 2001 Apr;7(4):812-7. PMID:11309327
- ↑ Zhou Q, Snipas S, Orth K, Muzio M, Dixit VM, Salvesen GS. Target protease specificity of the viral serpin CrmA. Analysis of five caspases. J Biol Chem. 1997 Mar 21;272(12):7797-800. PMID:9065443
- ↑ Sklate RT, Olcese MC, Maccallini GC, Sarmiento RG, Targovnik HM, Rivolta CM. Novel mutation p.A64D in the Serpina7 gene as a cause of partial thyroxine-binding globulin deficiency associated with increases affinity in transthyretin by a known p.A109T mutation in the TTR gene. Horm Metab Res. 2014 Feb;46(2):100-8. doi: 10.1055/s-0033-1358741. Epub 2013 Dec , 19. PMID:24356794 doi:http://dx.doi.org/10.1055/s-0033-1358741
- ↑ Pontisso P. Role of SERPINB3 in hepatocellular carcinoma. Ann Hepatol. 2014 Nov-Dec;13(6):722-7. PMID:25332258
- ↑ Yang GD, Yang XM, Lu H, Ren Y, Ma MZ, Zhu LY, Wang JH, Song WW, Zhang WM, Zhang R, Zhang ZG. SERPINA3 promotes endometrial cancer cells growth by regulating G2/M cell cycle checkpoint and apoptosis. Int J Clin Exp Pathol. 2014 Mar 15;7(4):1348-58. eCollection 2014. PMID:24817931
