Shikimate kinase
From Proteopedia
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== Structural highlights == | == Structural highlights == | ||
| - | The active site of SK contains the substrate | + | The active site of SK contains the substrate shikimate and an ADP molecule<ref>PMID:17183161</ref>. |
*<scene name='54/543316/Cv/5'>ADP binding site</scene>. Water molecules shown as red spheres. | *<scene name='54/543316/Cv/5'>ADP binding site</scene>. Water molecules shown as red spheres. | ||
*<scene name='54/543316/Cv/11'>Whole binding site</scene>. | *<scene name='54/543316/Cv/11'>Whole binding site</scene>. | ||
Revision as of 13:57, 29 August 2016
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3D Structures of shikimate kinase
Updated on 29-August-2016
References
- ↑ Saidemberg DM, Passarelli AW, Rodrigues AV, Basso LA, Santos DS, Palma MS. Shikimate kinase (EC 2.7.1.71) from Mycobacterium tuberculosis: kinetics and structural dynamics of a potential molecular target for drug development. Curr Med Chem. 2011;18(9):1299-310. PMID:21366533
- ↑ Gordon S, Simithy J, Goodwin DC, Calderon AI. Selective Mycobacterium tuberculosis Shikimate Kinase Inhibitors as Potential Antibacterials. Perspect Medicin Chem. 2015 Mar 15;7:9-20. doi: 10.4137/PMC.S13212. eCollection, 2015. PMID:25861218 doi:http://dx.doi.org/10.4137/PMC.S13212
- ↑ Dias MV, Faim LM, Vasconcelos IB, de Oliveira JS, Basso LA, Santos DS, de Azevedo WF Jr. Effects of the magnesium and chloride ions and shikimate on the structure of shikimate kinase from Mycobacterium tuberculosis. Acta Crystallogr Sect F Struct Biol Cryst Commun. 2007 Jan 1;63(Pt 1):1-6., Epub 2006 Dec 16. PMID:17183161 doi:10.1107/S1744309106046823
