Sphingomyelinase
From Proteopedia
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{{STRUCTURE_1zwx| PDB=1zwx | SIZE=400| SCENE= |right|CAPTION=Sphingomyelinase complex with glycerol and phosphate ion [[1zwx]] }} | {{STRUCTURE_1zwx| PDB=1zwx | SIZE=400| SCENE= |right|CAPTION=Sphingomyelinase complex with glycerol and phosphate ion [[1zwx]] }} | ||
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| - | + | '''Sphingomyelinase''' (SMase) is a hydrolase involved in sphingolipid metabolism. It catalyzes the breakdown of sphingomyelin (SM) to phosphocholine and ceramide<ref>PMID:11001563</ref>. The SMase is classified into 5 types according to their pH dependence and cation dependence. | |
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| - | '''Sphingomyelinase''' (SMase) is a hydrolase involved in sphingolipid metabolism. It catalyzes the breakdown of sphingomyelin (SM) to phosphocholine and ceramide. The SMase is classified into 5 types according to their pH dependence and cation dependence. | + | |
==3D structures of sphingomyelinase== | ==3D structures of sphingomyelinase== | ||
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[[2uyr]] – BcSMase (mutant)<br /> | [[2uyr]] – BcSMase (mutant)<br /> | ||
[[3wcx]] – SMase C – ''Streptomyces griseocarneus''<br /> | [[3wcx]] – SMase C – ''Streptomyces griseocarneus''<br /> | ||
| - | + | == References == | |
| + | <references/> | ||
[[Category:Topic Page]] | [[Category:Topic Page]] | ||
Revision as of 08:47, 31 August 2016
Sphingomyelinase (SMase) is a hydrolase involved in sphingolipid metabolism. It catalyzes the breakdown of sphingomyelin (SM) to phosphocholine and ceramide[1]. The SMase is classified into 5 types according to their pH dependence and cation dependence.
3D structures of sphingomyelinase
Updated on 31-August-2016
3rlh, 3rlg – SMase D (mutant) – Loxosceles intermedia
1xx1, 2f9r – SMase I – Loxosceles laeta
1zwx – SMase C – Listeria ivanovii
2ddr, 2dds, 2ddt – BcSMase + cation – Bacillus cereus
2uyr – BcSMase (mutant)
3wcx – SMase C – Streptomyces griseocarneus
References
- ↑ Chatterjee S. Neutral sphingomyelinase: past, present and future. Chem Phys Lipids. 1999 Nov;102(1-2):79-96. PMID:11001563
