Sphingomyelinase

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	**[[5fi9]] – mSMase + inhibitor<br />		**[[5fi9]] – mSMase + inhibitor<br />
	**[[5fic]] – mSMase + lipid<br />		**[[5fic]] – mSMase + lipid<br />
		+	**[[5jg8]] – hSMase – human<br />
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	== References ==		== References ==
	<references/>		<references/>
	[[Category:Topic Page]]		[[Category:Topic Page]]

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Revision as of 09:14, 31 August 2016

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Contents 1 Function 2 Disease 3 3D structures of sphingomyelinase 4 References

Function

Sphingomyelinase (SMase) is a hydrolase involved in sphingolipid metabolism. It catalyzes the breakdown of sphingomyelin (SM) to phosphocholine and ceramide^[1]. The SMase is classified into 5 types according to their pH dependence and cation dependence.

Disease

Mutations in acid SMase are found in patients with Niemann-Pick disease^[2].

3D structures of sphingomyelinase

Updated on 31-August-2016

References

1. ↑ Chatterjee S. Neutral sphingomyelinase: past, present and future. Chem Phys Lipids. 1999 Nov;102(1-2):79-96. PMID:11001563
2. ↑ Wasserstein MP, Aron A, Brodie SE, Simonaro C, Desnick RJ, McGovern MM. Acid sphingomyelinase deficiency: prevalence and characterization of an intermediate phenotype of Niemann-Pick disease. J Pediatr. 2006 Oct;149(4):554-9. PMID:17011332 doi:http://dx.doi.org/10.1016/j.jpeds.2006.06.034